DNA strand exchange and RecA homologs in meiosis

MS Brown, DK Bishop - Cold Spring Harbor perspectives …, 2015 - cshperspectives.cshlp.org
Homology search and DNA strand–exchange reactions are central to homologous
recombination in meiosis. During meiosis, these processes are regulated such that the …

Learning to tango with four (or more): the molecular basis of adaptation to polyploid meiosis

K Bomblies - Plant reproduction, 2023 - Springer
Polyploidy, which arises from genome duplication, has occurred throughout the history of
eukaryotes, though it is especially common in plants. The resulting increased size …

BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

W Zhao, JB Steinfeld, F Liang, X Chen, DG Maranon… - Nature, 2017 - nature.com
The tumour suppressor complex BRCA1–BARD1 functions in the repair of DNA double-
stranded breaks by homologous recombination. During this process, BRCA1–BARD1 …

Crucial roles of the BRCA1-BARD1 E3 ubiquitin ligase activity in homology-directed DNA repair

M Wang, W Li, N Tomimatsu, HY Corey, JH Ji, S Alejo… - Molecular cell, 2023 - cell.com
The tumor-suppressor breast cancer 1 (BRCA1) in complex with BRCA1-associated really
interesting new gene (RING) domain 1 (BARD1) is a RING-type ubiquitin E3 ligase that …

[HTML][HTML] Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair

J Lafrance-Vanasse, GJ Williams, JA Tainer - Progress in biophysics and …, 2015 - Elsevier
Abstract The Mre11-Rad50-Nbs1 (MRN) complex is a dynamic macromolecular machine
that acts in the first steps of DNA double strand break repair, and each of its components has …

Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination

J Xu, L Zhao, S Peng, H Chu, R Liang… - Nucleic Acids …, 2021 - academic.oup.com
Homologous recombination (HR) is a primary DNA double-strand breaks (DSBs) repair
mechanism. The recombinases Rad51 and Dmc1 are highly conserved in the RecA family; …

Exome sequencing of a primary ovarian insufficiency cohort reveals common molecular etiologies for a spectrum of disease

A Jolly, Y Bayram, S Turan, Z Aycan… - The Journal of …, 2019 - academic.oup.com
Context Primary ovarian insufficiency (POI) encompasses a spectrum of premature
menopause, including both primary and secondary amenorrhea. For 75% to 90% of …

Connecting by breaking and repairing: mechanisms of DNA strand exchange in meiotic recombination

CL Sansam, RJ Pezza - The FEBS journal, 2015 - Wiley Online Library
During prophase of meiosis I, homologous chromosomes interact and undergo
recombination. Successful completion of these processes is required in order for the …

Significance of ligand interactions involving Hop2-Mnd1 and the RAD51 and DMC1 recombinases in homologous DNA repair and XX ovarian dysgenesis

W Zhao, P Sung - Nucleic acids research, 2015 - academic.oup.com
Abstract The evolutionarily conserved Hop2-Mnd1 complex is a key cofactor for the meiosis-
specific recombinase Dmc1. However, emerging evidence has revealed that Hop2-Mnd1 is …

Identification of the meiotic toolkit in diatoms and exploration of meiosis-specific SPO11 and RAD51 homologs in the sexual species Pseudo-nitzschia multistriata and …

S Patil, S Moeys, P von Dassow, MJJ Huysman… - BMC genomics, 2015 - Springer
Background Sexual reproduction is an obligate phase in the life cycle of most eukaryotes.
Meiosis varies among organisms, which is reflected by the variability of the gene set …