DNA strand exchange and RecA homologs in meiosis
Homology search and DNA strand–exchange reactions are central to homologous
recombination in meiosis. During meiosis, these processes are regulated such that the …
recombination in meiosis. During meiosis, these processes are regulated such that the …
Learning to tango with four (or more): the molecular basis of adaptation to polyploid meiosis
K Bomblies - Plant reproduction, 2023 - Springer
Polyploidy, which arises from genome duplication, has occurred throughout the history of
eukaryotes, though it is especially common in plants. The resulting increased size …
eukaryotes, though it is especially common in plants. The resulting increased size …
BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing
The tumour suppressor complex BRCA1–BARD1 functions in the repair of DNA double-
stranded breaks by homologous recombination. During this process, BRCA1–BARD1 …
stranded breaks by homologous recombination. During this process, BRCA1–BARD1 …
Crucial roles of the BRCA1-BARD1 E3 ubiquitin ligase activity in homology-directed DNA repair
The tumor-suppressor breast cancer 1 (BRCA1) in complex with BRCA1-associated really
interesting new gene (RING) domain 1 (BARD1) is a RING-type ubiquitin E3 ligase that …
interesting new gene (RING) domain 1 (BARD1) is a RING-type ubiquitin E3 ligase that …
[HTML][HTML] Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair
J Lafrance-Vanasse, GJ Williams, JA Tainer - Progress in biophysics and …, 2015 - Elsevier
Abstract The Mre11-Rad50-Nbs1 (MRN) complex is a dynamic macromolecular machine
that acts in the first steps of DNA double strand break repair, and each of its components has …
that acts in the first steps of DNA double strand break repair, and each of its components has …
Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination
J Xu, L Zhao, S Peng, H Chu, R Liang… - Nucleic Acids …, 2021 - academic.oup.com
Homologous recombination (HR) is a primary DNA double-strand breaks (DSBs) repair
mechanism. The recombinases Rad51 and Dmc1 are highly conserved in the RecA family; …
mechanism. The recombinases Rad51 and Dmc1 are highly conserved in the RecA family; …
Exome sequencing of a primary ovarian insufficiency cohort reveals common molecular etiologies for a spectrum of disease
Context Primary ovarian insufficiency (POI) encompasses a spectrum of premature
menopause, including both primary and secondary amenorrhea. For 75% to 90% of …
menopause, including both primary and secondary amenorrhea. For 75% to 90% of …
Connecting by breaking and repairing: mechanisms of DNA strand exchange in meiotic recombination
CL Sansam, RJ Pezza - The FEBS journal, 2015 - Wiley Online Library
During prophase of meiosis I, homologous chromosomes interact and undergo
recombination. Successful completion of these processes is required in order for the …
recombination. Successful completion of these processes is required in order for the …
Significance of ligand interactions involving Hop2-Mnd1 and the RAD51 and DMC1 recombinases in homologous DNA repair and XX ovarian dysgenesis
Abstract The evolutionarily conserved Hop2-Mnd1 complex is a key cofactor for the meiosis-
specific recombinase Dmc1. However, emerging evidence has revealed that Hop2-Mnd1 is …
specific recombinase Dmc1. However, emerging evidence has revealed that Hop2-Mnd1 is …
Identification of the meiotic toolkit in diatoms and exploration of meiosis-specific SPO11 and RAD51 homologs in the sexual species Pseudo-nitzschia multistriata and …
S Patil, S Moeys, P von Dassow, MJJ Huysman… - BMC genomics, 2015 - Springer
Background Sexual reproduction is an obligate phase in the life cycle of most eukaryotes.
Meiosis varies among organisms, which is reflected by the variability of the gene set …
Meiosis varies among organisms, which is reflected by the variability of the gene set …