BACKGROUND Elucidating the genetic architecture of neuropsychiatric disorders remains a
major scientific and medical challenge. Emerging genomic technologies now permit the …

In contrast to the programmed nature of development, it is still a matter of debate whether
aging is an adaptive and regulated process, or merely a consequence arising from a …

Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and
BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the progressive loss of motor neurons. While several pathogenic mutations have been …

Three-prime repair exonuclease 1 (TREX1) is an anti-viral enzyme that cleaves nucleic
acids in the cytosol, preventing accumulation and a subsequent type I interferon-associated …

Loss of the nuclear RNA binding protein TAR DNA binding protein-43 (TDP-43) into
cytoplasmic aggregates is the strongest correlate to neurodegeneration in amyotrophic …

Abstract Long interspersed element 1 (LINE-1) is the only protein-coding transposon that is
active in humans. LINE-1 propagates in the genome using RNA intermediates via …

L1 retrotransposons are transposable elements and major contributors of genetic variation
in humans. Where L1 integrates into the genome can directly impact human evolution and …

Mice harbor∼ 2800 intact copies of the retrotransposon Long Interspersed Element 1 (L1).
The in vivo retrotransposition capacity of an L1 copy is defined by both its sequence integrity …

Repetitive elements (REs), such as transposable elements (TEs) and satellites, comprise
much of the genome. Here, we review how TEs and (peri) centromeric satellite DNA may …