Mechanisms of 3D cell migration

KM Yamada, M Sixt - Nature Reviews molecular cell biology, 2019 - nature.com
Cell migration is essential for physiological processes as diverse as development, immune
defence and wound healing. It is also a hallmark of cancer malignancy. Thousands of …

Mechanics of 3D cell–hydrogel interactions: experiments, models, and mechanisms

FJ Vernerey, S Lalitha Sridhar, A Muralidharan… - Chemical …, 2021 - ACS Publications
Hydrogels are highly water-swollen molecular networks that are ideal platforms to create
tissue mimetics owing to their vast and tunable properties. As such, hydrogels are promising …

Focal adhesion–independent cell migration

EK Paluch, IM Aspalter, M Sixt - Annual review of cell and …, 2016 - annualreviews.org
Cell migration is central to a multitude of physiological processes, including embryonic
development, immune surveillance, and wound healing, and deregulated migration is key to …

[HTML][HTML] The role and regulation of blebs in cell migration

EK Paluch, E Raz - Current opinion in cell biology, 2013 - Elsevier
Blebs are cellular protrusions that have been shown to be instrumental for cell migration in
development and disease. Bleb expansion is driven by hydrostatic pressure generated in …

Intracellular fluid mechanics: Coupling cytoplasmic flow with active cytoskeletal gel

A Mogilner, A Manhart - Annual Review of Fluid Mechanics, 2018 - annualreviews.org
The cell is a mechanical machine, and continuum mechanics of the fluid cytoplasm and the
viscoelastic deforming cytoskeleton play key roles in cell physiology. We review …

Supracellular migration–beyond collective cell migration

A Shellard, R Mayor - Journal of cell science, 2019 - journals.biologists.com
Collective cell migration is a highly complex process in which groups of cells move together.
A fundamental question is how cell ensembles can migrate efficiently. In some cases, the …

Glioblastoma Spheroid Invasion through Soft, Brain‐Like Matrices Depends on Hyaluronic Acid–CD44 Interactions

G Safarians, A Sohrabi, I Solomon… - Advanced …, 2023 - Wiley Online Library
Increased secretion of hyaluronic acid (HA), a glycosaminoglycan abundant in the brain
extracellular matrix (ECM), correlates with worse clinical outcomes for glioblastoma (GBM) …

Actin filament structures in migrating cells

J Lehtimäki, M Hakala, P Lappalainen - The Actin Cytoskeleton, 2017 - Springer
Cell migration is necessary for several developmental processes in multicellular organisms.
Furthermore, many physiological processes such as wound healing and immunological …

[HTML][HTML] Amoeboid swimming is propelled by molecular paddling in lymphocytes

L Aoun, A Farutin, N Garcia-Seyda, P Nègre, MS Rizvi… - Biophysical …, 2020 - cell.com
Mammalian cells developed two main migration modes. The slow mesenchymatous mode,
like crawling of fibroblasts, relies on maturation of adhesion complexes and actin fiber …

[HTML][HTML] Intracellular pressure dynamics in blebbing cells

W Strychalski, RD Guy - Biophysical journal, 2016 - cell.com
Blebs are pressure-driven protrusions that play an important role in cell migration,
particularly in three-dimensional environments. A bleb is initiated when the cytoskeleton …