[HTML][HTML] Collagen remodeling along cancer progression providing a novel opportunity for cancer diagnosis and treatment

K Song, Z Yu, X Zu, G Li, Z Hu, Y Xue - International Journal of Molecular …, 2022 - mdpi.com
The extracellular matrix (ECM) is a significant factor in cancer progression. Collagens, as the
main component of the ECM, are greatly remodeled alongside cancer development. More …

Bacterial biosynthesis of flavonoids: Overview, current biotechnology applications, challenges, and prospects

CO Okoye, H Jiang, Y Wu, X Li, L Gao… - Journal of Cellular …, 2023 - Wiley Online Library
Flavonoids are secondary metabolites present in plant organs and tissues. These natural
metabolites are the most prevalent and display a wide range of beneficial physiological …

[HTML][HTML] Deciphering the pharmacological mechanisms of Scutellaria baicalensis Georgi on oral leukoplakia by combining network pharmacology, molecular docking …

F Hou, Z Yu, YH Cheng, Y Liu, S Liang, F Zhang - Phytomedicine, 2022 - Elsevier
Background Oral leukoplakia (OLK), an uncharacterized pathological condition that occurs
as a white patch in the oral mucosa, is the most common precancerous condition. Scutellaria …

Research progress in the molecular mechanism of ferroptosis in Parkinson's disease and regulation by natural plant products

K Yang, L Zeng, J Zeng, Y Deng, S Wang, H Xu… - Ageing Research …, 2023 - Elsevier
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder of the
central nervous system after Alzheimer's disease. The current understanding of PD focuses …

[HTML][HTML] Baicalein as promising anticancer agent: A comprehensive analysis on molecular mechanisms and therapeutic perspectives

AKMH Morshed, S Paul, A Hossain, T Basak… - Cancers, 2023 - mdpi.com
Simple Summary Cancer is a multifactorial disease characterized by excessive cell
proliferation in a specific organ. The most common treatments include chemotherapy …

De Novo Production of Plant 4′-Deoxyflavones Baicalein and Oroxylin A from Ethanol in Crabtree-Negative Yeast

Z Qian, J Yu, X Chen, Y Kang, Y Ren, Q Liu… - ACS Synthetic …, 2022 - ACS Publications
Baicalein and oroxylin A are well-known medicinal 4′-deoxyflavones found mainly in the
roots of traditional medicinal plant Scutellaria baicalensis Georgi. However, extraction from …

[HTML][HTML] A therapeutic perspective of HDAC8 in different diseases: an overview of selective inhibitors

A Fontana, I Cursaro, G Carullo, S Gemma… - International Journal of …, 2022 - mdpi.com
Histone deacetylases (HDACs) are epigenetic enzymes which participate in transcriptional
repression and chromatin condensation mechanisms by removing the acetyl moiety from …

[HTML][HTML] Advances in Anti-Cancer Activities of Flavonoids in Scutellariae radix: Perspectives on Mechanism

Y Gu, QI Zheng, G Fan, R Liu - International Journal of Molecular …, 2022 - mdpi.com
Despite encouraging progresses in the development of novel therapies, cancer remains the
dominant cause of disease-related mortality and has become a leading economic and …

[HTML][HTML] Traditional Chinese medicine promotes bone regeneration in bone tissue engineering

ZR Gao, YZ Feng, YQ Zhao, J Zhao, YH Zhou, Q Ye… - Chinese medicine, 2022 - Springer
Bone tissue engineering (BTE) is a promising method for the repair of difficult-to-heal bone
tissue damage by providing three-dimensional structures for cell attachment, proliferation …

[HTML][HTML] Natural marine and terrestrial compounds as modulators of matrix metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer's disease

L Ciccone, J Vandooren, S Nencetti, E Orlandini - Pharmaceuticals, 2021 - mdpi.com
Several studies have reported neuroprotective effects by natural products. A wide range of
natural compounds have been investigated, and some of these may play a beneficial role in …