Dimensions in cell migration
The importance of cell migration for both normal physiological functions and disease
processes has been clear for the past 50 years. Although investigations of two-dimensional …
processes has been clear for the past 50 years. Although investigations of two-dimensional …
Mechanics of biological networks: from the cell cytoskeleton to connective tissue
From the cell cytoskeleton to connective tissues, fibrous networks are ubiquitous in
metazoan life as the key promoters of mechanical strength, support and integrity. In recent …
metazoan life as the key promoters of mechanical strength, support and integrity. In recent …
Stress controls the mechanics of collagen networks
Collagen is the main structural and load-bearing element of various connective tissues,
where it forms the extracellular matrix that supports cells. It has long been known that …
where it forms the extracellular matrix that supports cells. It has long been known that …
Three-dimensional force microscopy of cells in biopolymer networks
We describe a technique for the quantitative measurement of cell-generated forces in highly
nonlinear three-dimensional biopolymer networks that mimic the physiological situation of …
nonlinear three-dimensional biopolymer networks that mimic the physiological situation of …
Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions
Multiple attributes of the three-dimensional (3D) extracellular matrix (ECM) have been
independently implicated as regulators of cell motility, including pore size, crosslink density …
independently implicated as regulators of cell motility, including pore size, crosslink density …
Influence of the stiffness of three-dimensional alginate/collagen-I interpenetrating networks on fibroblast biology
CB da Cunha, DD Klumpers, WA Li, ST Koshy… - Biomaterials, 2014 - Elsevier
Wound dressing biomaterials are increasingly being designed to incorporate bioactive
molecules to promote healing, but the impact of matrix mechanical properties on the biology …
molecules to promote healing, but the impact of matrix mechanical properties on the biology …
Strain-controlled criticality governs the nonlinear mechanics of fibre networks
Disordered fibrous networks are ubiquitous in nature as major structural components of
living cells and tissues. The mechanical stability of networks generally depends on the …
living cells and tissues. The mechanical stability of networks generally depends on the …
Stress-induced plasticity of dynamic collagen networks
The structure and mechanics of tissues is constantly perturbed by endogenous forces
originated from cells, and at the same time regulate many important cellular functions such …
originated from cells, and at the same time regulate many important cellular functions such …
[HTML][HTML] Fibers in the extracellular matrix enable long-range stress transmission between cells
X Ma, ME Schickel, MD Stevenson… - Biophysical journal, 2013 - cell.com
Cells can sense, signal, and organize via mechanical forces. The ability of cells to
mechanically sense and respond to the presence of other cells over relatively long distances …
mechanically sense and respond to the presence of other cells over relatively long distances …
Viscoelastic properties of human pancreatic tumors and in vitro constructs to mimic mechanical properties
Pancreatic ductal adenocarcinoma (PDAC) is almost universally fatal, in large part due to a
protective fibrotic barrier generated by tumor-associated stromal (TAS) cells. This barrier is …
protective fibrotic barrier generated by tumor-associated stromal (TAS) cells. This barrier is …