The circadian clock is a biological timekeeping system to govern temporal rhythms of the
endocrine system and metabolism. The master pacemaker of biological rhythms is housed …

Cells change their metabolism in response to internal and external conditions by regulating
the trans-omic network, which is a global biochemical network with multiple omic layers …

Aims Obesity is the main cause of low-grade inflammation and oxidation, resulting in insulin
resistance. This study aimed to investigate the effects of a seed peptide lunasin on glucose …

Glucagon (GCGN) plays a key role in glucose and amino acid (AA) metabolism by
increasing hepatic glucose output. AA strongly stimulate GCGN secretion which regulates …

ABSTRACT Aims/Introduction Glucagon is secreted from pancreatic α‐cells and plays an
important role in amino acid metabolism in liver. Various animal models deficient in …

Currently, the bottom-up approach, in which proteins are digested by enzymes such as
trypsin prior to mass spectrometry, is the mainstream approach in mass spectrometer-based …

Hepatic glucose metabolism serves dual purposes: maintaining glucose homeostasis and
converting glucose into energy sources; however, the underlying mechanisms are unclear …

Each tissue has a dominant set of functional proteins required to mediate tissue-specific
functions. Epigenetic modifications, transcription, and translational efficiency control tissue …

Glucose homeostasis is maintained by modulation of metabolic flux. Enzymes and
metabolites regulate the involved metabolic pathways. Dysregulation of glucose …

With an increasing prevalence of obesity related kidney disease, exploring the mechanisms
of therapeutic method is of critical importance. Empagliflozin is a new antidiabetic agent with …