Vascular mechanotransduction

MJ Davis, S Earley, YS Li, S Chien - Physiological reviews, 2023 - journals.physiology.org
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Integrating the active process of hair cells with cochlear function

AJ Hudspeth - Nature Reviews Neuroscience, 2014 - nature.com
Uniquely among human senses, hearing is not simply a passive response to stimulation.
Our auditory system is instead enhanced by an active process in cochlear hair cells that …

[图书][B] An introduction to the physiology of hearing

JO Pickles - 1988 - academia.edu
5. Mechanisms of Transduction and Excitation in the Cochlea.. 1 1 2 A. Introduction.......... 1 1
2 B. The cytoskeleton of the transducer region..... 1 1 3 C. Mechanisms of transduction....... 1 …

Cellular mechanotransduction: putting all the pieces together again

DE Ingber - The FASEB journal, 2006 - Wiley Online Library
Analysis of cellular mechanotransduction, the mechanism by which cells convert mechanical
signals into biochemical responses, has focused on identification of critical …

TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear

B Pan, GS Géléoc, Y Asai, GC Horwitz, K Kurima… - Neuron, 2013 - cell.com
Sensory transduction in auditory and vestibular hair cells requires expression of
transmembrane channel-like (Tmc) 1 and 2 genes, but the function of these genes is …

Two-photon excitation fluorescence microscopy

PTC So, CY Dong, BR Masters… - Annual review of …, 2000 - annualreviews.org
▪ Abstract Two-photon fluorescence microscopy is one of the most important recent
inventions in biological imaging. This technology enables noninvasive study of biological …

[HTML][HTML] TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction

KY Kwan, AJ Allchorne, MA Vollrath, AP Christensen… - Neuron, 2006 - cell.com
TRPA1, a member of the transient receptor potential (TRP) family of ion channels, is
expressed by dorsal root ganglion neurons and by cells of the inner ear, where it has …

The physiology of mechanoelectrical transduction channels in hearing

R Fettiplace, KX Kim - Physiological reviews, 2014 - journals.physiology.org
Much is known about the mechanotransducer (MT) channels mediating transduction in hair
cells of the vertrbrate inner ear. With the use of isolated preparations, it is experimentally …

Mechanotransduction in mouse inner ear hair cells requires transmembrane channel–like genes

Y Kawashima, GSG Géléoc, K Kurima… - The Journal of …, 2011 - Am Soc Clin Investig
Inner ear hair cells convert the mechanical stimuli of sound, gravity, and head movement
into electrical signals. This mechanotransduction process is initiated by opening of cation …

Photon upmanship: why multiphoton imaging is more than a gimmick

W Denk, K Svoboda - Neuron, 1997 - cell.com
Lucent Technologies tum event had been predicted more than 60 years ago (Goeppert-
Mayer, 1931), but experimental confirmation Murray Hill, New Jersey 07974 was delayed …