Strategies for unlocking immunosuppression in the tumor microenvironment have been
investigated to overcome resistance to first-generation immune checkpoint blockade with …

Lymphocytes maturing in the thymus (T cells) are key factors in adaptive immunity and the
regulation of inflammation. The kynurenine pathway of tryptophan metabolism includes …

Abstract Indoleamine 2, 3-dioxygenase 1 (IDO1) is activated in chronic inflammatory states,
eg, in the aging process and age-related diseases. IDO1 enzyme catabolizes L-tryptophan …

Metabolism of tryptophan (Trp), an essential amino acid, represent a major metabolic
pathway that both promotes tumor cell intrinsic malignant properties as well as restricts …

Reprogramming of cellular metabolism is a hallmark of cancer. Cancer cells undergo
metabolic adaptations to maintain tumorigenicity and survive under the attack of immune …

To uncover underlying mechanisms associated with failure of indoleamine 2, 3-dioxygenase
1 (IDO1) blockade in clinical trials, we conducted a pilot, window-of-opportunity clinical study …

Immune checkpoint inhibitors (ICIs) targeting programmed cell death-1 (PD-1 or CD279)
have noticeably improved the treatment landscape of advanced cancer patients. Nivolumab …

Understanding the details of metabolic reprogramming in hepatocellular carcinoma (HCC) is
critical to improve stratification for therapy. Both multiomics analysis and cross-cohort …

Diet, serving as a vital source of nutrients, exerts a profound influence on human health and
disease progression. Recently, dietary interventions have emerged as promising adjunctive …

Although previously restricted to a limited number of medical conditions, there is a growing
appreciation that 'autoimmune'(or immune-mediated) processes are important aspects of a …