Tumorigenesis has long been thought to be a multistep process (Foulds, 1958); however,
only recently has it become possible to identify the molecular events that underlie the …

Malignant astrocytic gliomas such as glioblastoma are the most common and lethal
intracranial tumors. These cancers exhibit a relentless malignant progression characterized …

Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …

The development of cancer is due to the accumulation of multiple somatic mutations and in
some cases due to germline mutations, which occur in malignancies such as retinoblastoma …

Malignant brain tumours continue to be the cause of a disproportionate level of morbidity
and mortality across a wide range of individuals. The most common variants in the adult and …

Previous studies have demonstrated that allelic deletions of the short arm of chromosome 17
occur in over 75% of colorectal carcinomas. Twenty chromosome 17p markers were used to …

The new edition of the World Health Organization (WHO) book on 'Histological Typing of
Tumours of the Central Nervous System'reflects the progress in brain tumour classification …

This book on the World Health Organization (WHO) classification of tumours of the nervous
system reflects the view of a working group that convened for an editorial and consensus …

Malignant brain tumors strike deep into the psyche of those receiving and those delivering
the diagnosis. Malignant gliomas, the most common subtype of primary brain tumors, are …

A striking link exists between advanced age and increased incidence of cancer. Here I
review how several of the age-related molecular and physiological changes might act in …