Inhibitory effect of polyphenols from the whole green jackfruit flour against α-glucosidase, α-amylase, aldose reductase and glycation at multiple stages and their …

T Maradesha, SM Patil, KA Al-Mutairi, R Ramu… - Molecules, 2022 - mdpi.com
For the first time, α-glucosidase, α-amylase, aldose reductase, and glycation at multiple
stages inhibitory assays were used to explore the antidiabetic potential of whole unripe …

Defining the Role of Isoeugenol from Ocimum tenuiflorum against Diabetes Mellitus-Linked Alzheimer's Disease through Network Pharmacology and Computational …

RM Martiz, SM Patil, M Abdulaziz, A Babalghith… - Molecules, 2022 - mdpi.com
The present study involves the integrated network pharmacology and phytoinformatics-
based investigation of phytocompounds from Ocimum tenuiflorum against diabetes mellitus …

Discovery of novel coumarin derivatives as potential dual inhibitors against α-glucosidase and α-amylase for the management of post-prandial hyperglycemia via …

SM Patil, RM Martiz, AM Satish, AM Shbeer, M Ageel… - Molecules, 2022 - mdpi.com
Coumarin derivatives are proven for their therapeutic uses in several human diseases and
disorders such as inflammation, neurodegenerative disorders, cancer, fertility, and microbial …

Discovery of novel benzophenone integrated derivatives as anti-Alzheimer's agents targeting presenilin-1 and presenilin-2 inhibition: A computational approach

RM Martiz, SM Patil, R Ramu, J MK, AP… - PLoS …, 2022 - journals.plos.org
The most commonly accepted hypothesis of Alzheimer's disease (AD) is the amyloid
hypothesis caused due to formation of accumulation of Aβ42 isoform, which leads to …

Computer-Aided Screening of Phytoconstituents from Ocimum tenuiflorum against Diabetes Mellitus Targeting DPP4 Inhibition: A Combination of Molecular Docking …

H Sajal, SM Patil, R Raj, AM Shbeer, M Ageel, R Ramu - Molecules, 2022 - mdpi.com
Diabetes mellitus is a major global health concern in the current scenario which is chiefly
characterized by the rise in blood sugar levels or hyperglycemia. In the context, DPP4 …

Integrated network pharmacology and molecular modeling approach for the discovery of novel potential MAPK3 inhibitors from whole green jackfruit flour targeting …

T Maradesha, RM Martiz, SM Patil, A Prasad… - Plos one, 2023 - journals.plos.org
The current study investigates the effectiveness of phytocompounds from the whole green
jackfruit flour methanol extract (JME) against obesity-linked diabetes mellitus using …

[HTML][HTML] Pharmacoinformatics based screening discovers swertianolin from Lavandula angustifolia as a novel neuromodulator targeting epilepsy, depression, and …

SM Patil, KA Al-Mutairi, N Firdose, R Ramu… - South African Journal of …, 2022 - Elsevier
In the present study, we evaluate the pharmacological significance of phytoconstituents
derived from Lavandula angustifolia with respect to anticonvulsant, antidepressant, and …

Phyto-Computational Intervention of Diabetes Mellitus at Multiple Stages Using Isoeugenol from Ocimum tenuiflorum: A Combination of Pharmacokinetics and …

RM Martiz, SM Patil, D Thirumalapura Hombegowda… - Molecules, 2022 - mdpi.com
In the present study, the anti-diabetic potential of Ocimum tenuiflorum was investigated
using computational techniques for α-glucosidase, α-amylase, aldose reductase, and …

Molecular insights into the in silico discovery of corilagin from Terminalia chebula as a potential dual inhibitor of SARS-CoV-2 structural proteins

S Pradeep, SM Patil, C Dharmashekara… - Journal of …, 2023 - Taylor & Francis
The spike (S) glycoprotein and nucleocapsid (N) proteins are the crucial pathogenic proteins
of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) virus during its …

New insights on the phytochemical intervention for the treatment of neuropsychiatric disorders using the leaves of Michelia champaca: an in vivo and in silico …

P VH, J MK, R HR, VKN Shivamurthy… - Pharmaceutical …, 2022 - Taylor & Francis
Abstract Context Michelia champaca L.(Magnoliaceae) has been known since ancient times
for its rich medicinal properties. Objective The ethanol extract of Michelia champaca leaves …