Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …

Breast cancer (BC) involves complex signaling networks characterized by extensive cross-
communication and feedback loops between and within multiple signaling cascades. Many …

Converting tumor-associated macrophages (TAMs) from the M2 to the M1 phenotype is
considered an effective strategy for cancer therapy. TRAF3 is known to regulate NF-κB …

Background The management of advanced clear cell renal cell carcinoma (ccRCC) remains
a major challenge in clinical practice, and the construction of more reliable prognostic …

Phosphoglycerate dehydrogenase (PHGDH) has emerged as a crucial factor in
macromolecule synthesis, neutralizing oxidative stress, and regulating methylation reactions …

Exposure to crystalline silica (CS) particles in worksites and dwellings can lead to silicosis
due to excessive fibroblast activation. Considering their immuno-regulatory activities, the …

The tumor microenvironment (TME) plays an important role in various stages of tumor
generation, metastasis, and evasion of immune monitoring and treatment. TME targeted …

Simple Summary Breast cancer is the most prevalent cancer in women worldwide, and it
exhibits a growing incidence. An increasing number of studies showed the complex …

Tumor-associated platelets can bind to tumor cells and protect circulating tumor cells from
NK-mediated immune surveillance. Tumor-associated platelets secrete cytokines to induce …

Pazopanib (PAZ), an oral multi-tyrosine kinase inhibitor, demonstrates promising cytostatic
activities against various human cancers. However, its clinical utility is limited by substantial …