Oncolytic virotherapy
SJ Russell, KW Peng, JC Bell - Nature biotechnology, 2012 - nature.com
Oncolytic virotherapy is an emerging treatment modality that uses replication-competent
viruses to destroy cancers. Recent advances include preclinical proof of feasibility for a …
viruses to destroy cancers. Recent advances include preclinical proof of feasibility for a …
New viruses for cancer therapy: meeting clinical needs
TS Miest, R Cattaneo - Nature reviews microbiology, 2014 - nature.com
Early-stage clinical trials of oncolytic virotherapy have reported the safety of several virus
platforms, and viruses from three families have progressed to advanced efficacy trials. In …
platforms, and viruses from three families have progressed to advanced efficacy trials. In …
Oncolytic virotherapy evolved into the fourth generation as tumor immunotherapy
X Wang, Y Shen, X Wan, X Hu, WQ Cai, Z Wu… - Journal of Translational …, 2023 - Springer
Background Oncolytic virotherapy (OVT) is a promising anti-tumor modality that utilizes
oncolytic viruses (OVs) to preferentially attack cancers rather than normal tissues. With the …
oncolytic viruses (OVs) to preferentially attack cancers rather than normal tissues. With the …
Retargeting strategies for oncolytic herpes simplex viruses
G Campadelli-Fiume, B Petrovic, V Leoni, T Gianni… - Viruses, 2016 - mdpi.com
Most of the oncolytic herpes simplex viruses (HSVs) exhibit a high safety profile achieved
through attenuation. They carry defects in virulence proteins that antagonize host cell …
through attenuation. They carry defects in virulence proteins that antagonize host cell …
Intravenous injections of a rationally selected oncolytic herpes virus as a potent virotherapy for hepatocellular carcinoma
Y Luo, C Lin, W Ren, F Ju, Z Xu, H Liu, Z Yu… - Molecular Therapy …, 2019 - cell.com
As a clinical setting in which novel treatment options are urgently needed, hepatocellular
carcinoma (HCC) exhibits intriguing opportunities for oncolytic virotherapy. Here we report …
carcinoma (HCC) exhibits intriguing opportunities for oncolytic virotherapy. Here we report …
Progress in clinical oncolytic virus-based therapy for hepatocellular carcinoma
AH Jebar, F Errington-Mais, RG Vile… - Journal of General …, 2015 - microbiologyresearch.org
Hepatocellular carcinoma (HCC) carries a dismal prognosis, with advanced disease being
resistant to both radiotherapy and conventional cytotoxic drugs, whilst anti-angiogenic drugs …
resistant to both radiotherapy and conventional cytotoxic drugs, whilst anti-angiogenic drugs …
Bacteriophage-derived vectors for targeted cancer gene therapy
MZI Pranjol, A Hajitou - Viruses, 2015 - mdpi.com
Cancer gene therapy expanded and reached its pinnacle in research in the last decade.
Both viral and non-viral vectors have entered clinical trials, and significant successes have …
Both viral and non-viral vectors have entered clinical trials, and significant successes have …
Botulinum neurotoxin light chains expressed by defective herpes simplex virus type-1 vectors cleave SNARE proteins and inhibit CGRP release in rat sensory neurons
C Joussain, O Le Coz, A Pichugin, P Marconi, F Lim… - Toxins, 2019 - mdpi.com
A set of herpes simplex virus type 1 (HSV-1) amplicon vectors expressing the light chains
(LC) of botulinum neurotoxins (BoNT) A, B, C, D, E and F was constructed. Their properties …
(LC) of botulinum neurotoxins (BoNT) A, B, C, D, E and F was constructed. Their properties …
Delivery approaches of gene therapy in hepatocellular carcinoma
F Duan, MGEH Lam - Anticancer research, 2013 - ar.iiarjournals.org
Gene therapy has the potential to provide therapeutic benefits to hepatocellular carcinoma
(HCC) patients and has been the subject of intense pre-clinical and clinical research in …
(HCC) patients and has been the subject of intense pre-clinical and clinical research in …
Co-culture of primary human tumor hepatocytes from patients with hepatocellular carcinoma with autologous peripheral blood mononuclear cells: study of their in vitro …
PP Doumba, M Nikolopoulou, IP Gomatos… - BMC …, 2013 - Springer
Background Many studies have suggested that the immune response may play a crucial role
in the progression of hepatocellular carcinoma (HCC). Therefore, our aim was to establish a …
in the progression of hepatocellular carcinoma (HCC). Therefore, our aim was to establish a …