Cerebral palsy is caused by injury or developmental disturbances to the immature brain and
leads to substantial motor, cognitive, and learning deficits. In addition to developmental …

Hypoxia–ischemia before or around the time of birth occurs in approximately 2/1000 live
births and is associated with a high risk of death or lifelong disability. Therapeutic …

Previously our laboratory has shown that ketamine exposure (24h of clinically relevant
anesthesia) causes significant increases in neuronal cell death in perinatal rhesus monkeys …

Background Moderate cooling after birth asphyxia is associated with substantial reductions
in death and disability, but additional therapies might provide further benefit. We assessed …

Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating disease that primarily
causes neuronal and white matter injury and is among the leading cause of death among …

General anesthetics are commonly used in major surgery. To achieve the depth of
anesthesia for surgery, patients are being subjected to a variety of general anesthetics …

Hypothermia therapy is an old and important method of neuroprotection. Until now, many
neurological diseases such as stroke, traumatic brain injury, intracranial pressure elevation …

Therapeutic hypothermia is a standard of care for infants≥ 36 weeks gestational age (GA)
with moderate-to-severe hypoxic-ischemic encephalopathy. Because some studies included …

The possibility that hypothermia during or after resuscitation from asphyxia at birth, or
cardiac arrest in adults, might reduce evolving damage has tantalized clinicians for a very …

Background Anesthetics, including isoflurane and nitrous oxide, an antagonist of the N-
methyl-D-aspartate subtype of the glutamate receptor, have been demonstrated to induce …