Located at the skin surface, keratinocytes (KCs) are constantly exposed to external stimuli
and are the first responders to invading pathogens and injury. Upon skin injury, activated …

Historically, the term 'keratin'stood for all of the proteins extracted from skin modifications,
such as horns, claws and hooves. Subsequently, it was realized that this keratin is actually a …

The authors have recently identified a new cytokeratin (CK) polypeptide, CK 20, whose
expression is almost entirely confined to the gastric and intestinal epithelium, urothelium …

A major cytoskeletal polypeptide (Mr approximately 46,000; protein IT) of human intestinal
epithelium was characterized by biochemical and immunological methods. The polypeptide …

A construct containing approximately 2500 base pairs (bp) of 5'upstream and approximately
700 bp of 3'downstream sequence was used to drive the expression of an intronless human …

Because of extraordinarily tight coiled-coil associations of type I and type II keratins, the
composition and structure of keratin subunits has been difficult to determine. We report here …

Keratins K14 and K5 have long been considered to be biochemical markers of the stratified
squamous epithelia, including epidermis (Moll, R., W. Franke, D. Schiller, B. Geiger, and R …

We report here the isolation and characterization of three antisera, each of which is specific
for a single keratin from one of the three different pairs (K1/K10, K14/K5, K16/K6) that are …

Extracellular matrix is considered to play an important role in determining the phenotype of
cells with which it interacts. Here we have investigated the possibility that extracellular matrix …

Application of SEREX (serological analysis of recombinant tumor cDNA expression libraries)
to different tumor types has led to the identification of several categories of human tumor …