Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases

C Sturgeon, A Fasano - Tissue barriers, 2016 - Taylor & Francis
Beside digesting nutrients and absorbing solutes and electrolytes, the intestinal epithelium
with its barrier function is in charge of a tightly controlled antigen trafficking from the …

[HTML][HTML] Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer

A Fasano - Physiological reviews, 2011 - journals.physiology.org
The primary functions of the gastrointestinal tract have traditionally been perceived to be
limited to the digestion and absorption of nutrients and to electrolytes and water …

[HTML][HTML] Plasma markers of disrupted gut permeability in severe COVID-19 patients

LB Giron, H Dweep, X Yin, H Wang, M Damra… - Frontiers in …, 2021 - frontiersin.org
A disruption of the crosstalk between the gut and the lung has been implicated as a driver of
severity during respiratory-related diseases. Lung injury causes systemic inflammation …

Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms

DR Rose, H Yang, G Serena, C Sturgeon, B Ma… - Brain, behavior, and …, 2018 - Elsevier
Objectives Many studies have reported the increased presence of gastrointestinal (GI)
symptoms in children with autism spectrum disorders (ASD). Altered microbiome profiles …

Zonulin, regulation of tight junctions, and autoimmune diseases

A Fasano - Annals of the New York Academy of Sciences, 2012 - Wiley Online Library
Recent studies indicate that besides digestion and absorption of nutrients and water and
electrolytes homeostasis, another key function of the intestine is to regulate the trafficking of …

[HTML][HTML] Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease

DE Matei, M Menon, DG Alber, AM Smith… - Med, 2021 - cell.com
Background Evidence suggests an important role for gut-microbiota dysbiosis in the
development of rheumatoid arthritis (RA). The link between changes in gut bacteria and the …

Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2

A Tripathi, KM Lammers, S Goldblum… - Proceedings of the …, 2009 - National Acad Sciences
Increased intestinal permeability (IP) has emerged recently as a common underlying
mechanism in the pathogenesis of allergic, inflammatory, and autoimmune diseases. The …

[HTML][HTML] The dietary intake of wheat and other cereal grains and their role in inflammation

K De Punder, L Pruimboom - Nutrients, 2013 - mdpi.com
Wheat is one of the most consumed cereal grains worldwide and makes up a substantial
part of the human diet. Although government-supported dietary guidelines in Europe and the …

Haptoglobin

CBF Andersen, K Stødkilde, KL Saederup… - Antioxidants & Redox …, 2017 - liebertpub.com
Abstract Significance: Haptoglobin (Hp) is an abundant human plasma protein that tightly
captures hemoglobin (Hb) during hemolysis. The Hb-Hp complex formation reduces the …

Zonulin as a potential putative biomarker of risk for shared type 1 diabetes and celiac disease autoimmunity

LK Wood Heickman, MD DeBoer… - … research and reviews, 2020 - Wiley Online Library
The incidence of type 1 diabetes (T1D) is increasing annually, in addition to other childhood‐
onset autoimmune diseases. This review is inspired by recent strides in research defining …