1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

Protein ubiquitination is a key post-translational modification in regulating many
fundamental cellular processes and dysregulation of these processes can give rise to a vast …

The agrochemical and pharmaceutical sectors have relied heavily on heterocyclic aromatic
compounds. This work comprises the synthesis and investigation of a hydrazine derivative …

In this study, the solvation effects, structural characterization, and biological properties of the
Fmoc-L-glutamic acid 5-tert-butyl ester (Fmoc-L-Glu (OtBu)) were described with …

The reversible attachment of ubiquitin (Ub) and ubiquitin like modifiers (Ubls) to proteins are
crucial post-translational modifications (PTMs) for many cellular processes. Not only do cells …

Interest in bacterial proteasomes was sparked by the discovery that proteasomal
degradation is required for the pathogenesis of Mycobacterium tuberculosis, one of the …

Prokaryotic ubiquitin-like protein (Pup) is covalently attached to target proteins by the ligase
PafA, tagging substrates for proteasomal degradation. The crystal structure of Pup in …

The protein degradation machinery of Mycobacterium tuberculosis includes a proteasome
and a ubiquitin-like protein (Pup). Proteasome accessory factor A (PafA) attaches Pup to …

Tuberculosis is a global health problem caused by infection with the Mycobacterium
tuberculosis (Mtb) bacteria. Although antibiotic treatment has dramatically reduced the …

Deamidase of Pup (Dop), the prokaryotic ubiquitin-like protein (Pup)-deconjugating enzyme,
is critical for the full virulence of Mycobacterium tuberculosis and is unique to bacteria …