Background The dietary consumption of cuprizone–a copper chelator–has long been known
to induce demyelination of specific brain structures and is widely used as model of multiple …

Multiple Sclerosis (MS) is a neuroinflammatory disorder, which is histopathologically
characterized by multifocal inflammatory demyelinating lesions affecting both the central …

Once believed to be part of the nervenkitt or “nerve glue” network in the central nervous
system (CNS), oligodendroglial cells now have established roles in key neurological …

Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative
disease of the central nervous system (CNS). In people with MS, impaired remyelination and …

The feeding of cuprizone (CPZ) to animals has been extensively used to model the
processes of demyelination and remyelination, with many papers adopting a narrative linked …

Multiple Sclerosis (MS) is traditionally considered an autoimmune-mediated demyelinating
disease, the pathoetiology of which is unknown. However, the key question remains whether …

Oxidative stress critically contributes to the pathogenesis of a variety of neurodegenerative
diseases such as multiple sclerosis. Astrocytes are the main regulators of oxidative …

Metabolic syndrome is a key risk factor and co-morbidity in multiple sclerosis (MS) and other
neurological conditions, such that a better understanding of how a high fat diet contributes to …

Functional disruption and neuronal loss followed by progressive dysfunction of the nervous
system underlies the pathogenesis of numerous disorders defined as “neurodegenerative …

Multiple sclerosis (MS) is a progressive chronic inflammatory autoimmune disease of the
myelin sheath, and melatonin is a powerful antioxidant and anti-inflammatory agent. The …