Liver fibrosis is a substantial risk factor for the development and progression of liver cancer,
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …

The extracellular matrix (ECM) provides physical support and imparts significant
biochemical and mechanical cues to cells. Matrix stiffening is a hallmark of liver fibrosis and …

Liver sinusoidal endothelial cells (LSECs) are key players in maintaining hepatic
homeostasis. They also play crucial roles during liver injury by communicating with liver cell …

Disorders such as pancreatic or hepatic fibrosis are a cruel reminder that disruption of the
delicate physiological balance could result in severe pathological consequences. Fibrosis is …

Background & Aims Hepatic stellate cells (HSCs) are the key drivers of fibrosis in metabolic
dysfunction-associated steatohepatitis (MASH), the fastest growing cause of hepatocellular …

Liver fibrosis is characterized by the activation of perivascular hepatic stellate cells (HSCs),
the release of fibrogenic nanosized extracellular vesicles (EVs), and increased HSC …

Matrix stiffness is a central modulator of hepatic stellate cells (HSCs) activation and hepatic
fibrogenesis. However, the long non-coding RNAs (lncRNAs)-regulated transcriptional …

The hepatic sinusoids are composed of liver sinusoidal endothelial cells (LSEC), which are
surrounded by hepatic stellate cells (HSC) and contain liver-resident macrophages called …

The growing recognition of the role of the gut microbiome's impact on alcohol-related
diseases, especially in alcohol-associated liver disease, emphasizes the need to …

Chronic liver injury leads to progressive liver fibrosis and ultimately cirrhosis, a major cause
of morbidity and mortality worldwide. However, there are currently no effective anti-fibrotic …