[HTML][HTML] Platelet activation mechanisms and consequences of immune thrombocytopenia

S Sun, RT Urbanus, H Ten Cate, PG de Groot… - Cells, 2021 - mdpi.com
Autoimmune disorders are often associated with low platelet count or thrombocytopenia. In
immune-induced thrombocytopenia (IIT), a common mechanism is increased platelet …

Immune thrombocytopenic purpura secondary to COVID‐19 vaccination: a systematic review

A Bidari, S Asgarian, A Pour Mohammad… - European Journal of …, 2023 - Wiley Online Library
Introduction This systematic review aimed to retrieve patients diagnosed with de novo
immune thrombocytopenic purpura (ITP) after COVID‐19 immunization to determine their …

Fc receptors gone wrong: a comprehensive review of their roles in autoimmune and inflammatory diseases

E Chalayer, B Gramont, F Zekre… - Autoimmunity …, 2022 - Elsevier
Systemic autoimmune and inflammatory diseases have a complex and only partially known
pathophysiology with various abnormalities involving all the components of the immune …

[HTML][HTML] Immune thrombocytopenic purpura as a hemorrhagic versus thrombotic disease: an updated insight into pathophysiological mechanisms

CC Tărniceriu, LL Hurjui, ID Florea, I Hurjui, I Gradinaru… - Medicina, 2022 - mdpi.com
Immune thrombocytopenic purpura (ITP) is a blood disorder characterized by a low platelet
count of (less than 100× 109/L). ITP is an organ-specific autoimmune disease in which the …

Rilzabrutinib versus placebo in adults and adolescents with persistent or chronic immune thrombocytopenia: LUNA 3 phase III study

DJ Kuter, JB Bussel, W Ghanima… - Therapeutic …, 2023 - journals.sagepub.com
Background: Immune thrombocytopenia (ITP) is characterized by primarily autoantibody-
mediated platelet destruction and impaired platelet production resulting in thrombocytopenia …

Study of platelet kinetics in immune thrombocytopenia to predict splenectomy response

A Mendoza, MT Álvarez‐Román… - British Journal of …, 2024 - Wiley Online Library
Despite the efficacy of splenectomy for chronic immune thrombocytopenia (ITP), its
considerable failure rate and its possible related complications prove the need for further …

[HTML][HTML] Cellular surface plasmon resonance-based detection of anti-HPA-1a antibody glycosylation in fetal and neonatal alloimmune thrombocytopenia

Z Szittner, AEH Bentlage, AR Temming… - Frontiers in …, 2023 - frontiersin.org
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) can occur due to maternal IgG
antibodies targeting platelet antigens, causing life-threatening bleeding in the neonate …

[HTML][HTML] Safety and efficacy of tyrosine kinase inhibitors in immune thrombocytopenic purpura: a systematic review of clinical trials

MA Ali, MY Anwar, W Aiman, G Dhanesar, Z Omar… - Journal of …, 2023 - mdpi.com
Immune thrombocytopenic purpura (ITP) is an acquired antibody or cell-mediated platelet
damage or decreased platelet production. Steroids, IV immunoglobulins (IVIG), and Rho-anti …

[HTML][HTML] Novel therapies to address unmet needs in ITP

ME Mingot-Castellano, JM Bastida… - Pharmaceuticals, 2022 - mdpi.com
Primary immune thrombocytopenia (ITP) is an autoimmune disorder that causes low platelet
counts and subsequent bleeding risk. Although current corticosteroid-based ITP therapies …

[HTML][HTML] Proposal for a new protocol for the management of immune thrombocytopenia (ITP)

TJ González-López, D Provan - Advances in Therapy, 2022 - Springer
For many decades immune thrombocytopenia (ITP) was managed using therapies which
had not undergone randomised clinical trials and included corticosteroids, immune …