Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade
RB Patel, R Hernandez, P Carlson… - Science translational …, 2021 - science.org
Molecular and cellular effects of radiotherapy on tumor microenvironment (TME) can help
prime and propagate antitumor immunity. We hypothesized that delivering radiation to all …
prime and propagate antitumor immunity. We hypothesized that delivering radiation to all …
[HTML][HTML] Temporal analysis of type 1 interferon activation in tumor cells following external beam radiotherapy or targeted radionuclide therapy
Rationale: Clinical interest in combining targeted radionuclide therapies (TRT) with
immunotherapies is growing. External beam radiation therapy (EBRT) activates a type 1 …
immunotherapies is growing. External beam radiation therapy (EBRT) activates a type 1 …
Preclinical voxel-based dosimetry in theranostics: a review
Due to the increasing use of preclinical targeted radionuclide therapy (TRT) studies for the
development of novel theranostic agents, several studies have been performed to accurately …
development of novel theranostic agents, several studies have been performed to accurately …
Safety and feasibility of an in situ vaccination and immunomodulatory targeted radionuclide combination immuno-radiotherapy approach in a comparative …
K Magee, IR Marsh, MM Turek, J Grudzinski… - PLoS …, 2021 - journals.plos.org
Rationale Murine syngeneic tumor models have revealed efficacious systemic antitumor
responses following primary tumor in situ vaccination combined with targeted radionuclide …
responses following primary tumor in situ vaccination combined with targeted radionuclide …
[HTML][HTML] Antitumor efficacy of 90Y-NM600 targeted radionuclide therapy and PD-1 blockade is limited by regulatory T cells in murine prostate tumors
Background Systemic radiation treatments that preferentially irradiate cancer cells over
normal tissue, known as targeted radionuclide therapy (TRT), have shown significant …
normal tissue, known as targeted radionuclide therapy (TRT), have shown significant …
PARaDIM: a PHITS-based Monte Carlo tool for internal dosimetry with tetrahedral mesh computational phantoms
Mesh-type and voxel-based computational phantoms comprise the current state of the art for
internal dose assessment via Monte Carlo simulations but excel in different aspects, with …
internal dose assessment via Monte Carlo simulations but excel in different aspects, with …
Image-based dosimetry in dogs and cross-reactivity with human tissues of IGF2R-targeting human antibody
KJH Allen, O Kwon, MR Hutcheson, JJ Grudzinski… - Pharmaceuticals, 2023 - mdpi.com
Background: Osteosarcoma (OS) represents the most common primary bone tumor in
humans and in companion dogs, being practically phenotypically identical. There is a need …
humans and in companion dogs, being practically phenotypically identical. There is a need …
Preclinical characterization of 86/90Y-NM600 in a variety of murine and human cancer tumor models
We characterize the in vivo biodistribution and tumor selectivity of 86Y-NM600, a theranostic
alkylphosphocholine radiometal chelate with broad tumor selectivity, in a variety of …
alkylphosphocholine radiometal chelate with broad tumor selectivity, in a variety of …
[HTML][HTML] Myeloid-derived suppressor cells attenuate the antitumor efficacy of radiopharmaceutical therapy using 90Y-NM600 in combination with androgen deprivation …
Methods 6-week-old male FVB mice were implanted subcutaneously with Myc-CaP tumor
cells and given a single intravenous injection of 90 Y-NM600, in combination with ADT …
cells and given a single intravenous injection of 90 Y-NM600, in combination with ADT …
Low-Dose Radiation Potentiates the Propagation of Anti-Tumor Immunity against Melanoma Tumor in the Brain after In Situ Vaccination at a Tumor outside the Brain
PA Clark, RN Sriramaneni, AM Bates… - Radiation …, 2021 - meridian.allenpress.com
Brain metastases develop in over 60% of advanced melanoma patients and negatively
impact quality of life and prognosis. In a murine melanoma model, we previously showed …
impact quality of life and prognosis. In a murine melanoma model, we previously showed …