Importance Schizophrenia is a common, severe mental illness that most clinicians will
encounter regularly during their practice. This report provides an overview of the clinical …

The mesolimbic hypothesis has been a central dogma of schizophrenia for decades,
positing that aberrant functioning of midbrain dopamine projections to limbic regions causes …

Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …

The dopamine projection from ventral tegmental area (VTA) to nucleus accumbens (NAc) is
critical for motivation to work for rewards and reward-driven learning. How dopamine …

Dopamine neurons are characterized by their response to unexpected rewards, but they
also fire during movement and aversive stimuli. Dopamine neuron diversity has been …

Dopamine is a critical modulator of both learning and motivation. This presents a problem:
how can target cells know whether increased dopamine is a signal to learn or to move? It is …

The striatum is essential for learning which actions lead to reward and for implementing
those actions. Decades of experimental and theoretical work have led to several influential …

A large body of work has aimed to define the precise information encoded by dopaminergic
projections innervating the nucleus accumbens (NAc). Prevailing models are based on …

Dopamine (DA) is a key neurotransmitter involved in multiple physiological functions
including motor control, modulation of affective and emotional states, reward mechanisms …

Fiber photometry enables recording of population neuronal calcium dynamics in awake
mice. While the popularity of fiber photometry has grown in recent years, it remains unclear …