Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence

P Li, W Jiang, Q Yu, W Liu, P Zhou, J Li, J Xu, B Xu… - Nature, 2017 - nature.com
Interferon-inducible guanylate-binding proteins (GBPs) mediate cell-autonomous
antimicrobial defences,. Shigella flexneri, a Gram-negative cytoplasmic free-living bacterium …

[HTML][HTML] Intracellular replication of the well-armed pathogen Burkholderia pseudomallei

SJ Willcocks, CC Denman, HS Atkins… - Current opinion in …, 2016 - Elsevier
Highlights•Burkholderia pseudomallei (BPS) possess a variety of virulence factors that
facilitate survival at different stages of intracellular infection in a variety of cell types.•At the …

[HTML][HTML] Protein–protein interactions and the spatiotemporal dynamics of bacterial outer membrane proteins

C Kleanthous, P Rassam, CG Baumann - Current opinion in structural …, 2015 - Elsevier
Highlights•We discuss spatiotemporal patterning in the bacterial outer membrane.•
Promiscuous interactions between outer membrane proteins govern their …

Utilizing Whole Fusobacterium Genomes To Identify, Correct, and Characterize Potential Virulence Protein Families

A Umaña, BE Sanders, CC Yoo… - Journal of …, 2019 - Am Soc Microbiol
Fusobacterium spp. are Gram-negative, anaerobic, opportunistic pathogens involved in
multiple diseases, including a link between the oral pathogen Fusobacterium nucleatum and …

Genetic variation, structural analysis, and virulence implications of BimA and BimC in clinical isolates of Burkholderia pseudomallei in Thailand

CMS Cagape, R Seng, N Saiprom, S Tandhavanant… - Scientific Reports, 2024 - nature.com
Melioidosis is a life-threatening tropical disease caused by an intracellular gram-negative
bacterium Burkholderia pseudomallei. B. pseudomallei polymerizes the host cell actin …

Super-resolution imaging of protein secretion systems and the cell surface of gram-negative bacteria

SD Gunasinghe, CT Webb, KD Elgass… - Frontiers in cellular …, 2017 - frontiersin.org
Gram-negative bacteria have a highly evolved cell wall with two membranes composed of
complex arrays of integral and peripheral proteins, as well as phospholipids and glycolipids …

Burkholderia pseudomallei BimC Is Required for Actin-Based Motility, Intracellular Survival, and Virulence

V Srinon, S Chaiwattanarungruengpaisan… - Frontiers in cellular …, 2019 - frontiersin.org
The intracellular pathogen Burkholderia pseudomallei, the etiological agent of melioidosis in
humans and various animals, is capable of survival and movement within the cytoplasm of …

Burkholderia pseudomallei pathogenesis and survival in different niches

CH Yip, AK Ghazali, S Nathan - Biochemical Society …, 2020 - portlandpress.com
Burkholderia pseudomallei (Bp) is the causative agent of melioidosis, a disease of the
tropics with high clinical mortality rates. To date, no vaccines are approved for melioidosis …

Discovery of a novel periplasmic protein that forms a complex with a trimeric autotransporter adhesin and peptidoglycan

M Ishikawa, S Yoshimoto, A Hayashi… - Molecular …, 2016 - Wiley Online Library
Trimeric autotransporter adhesins (TAAs), fibrous proteins on the cell surface of Gram‐
negative bacteria, have attracted attention as virulence factors. However, little is known …

Phenotypic Characterization of a Novel Virulence-Factor Deletion Strain of Burkholderia mallei That Provides Partial Protection against Inhalational Glanders in Mice

JA Bozue, S Chaudhury, K Amemiya, J Chua… - Frontiers in cellular …, 2016 - frontiersin.org
Burkholderia mallei (Bm) is a highly infectious intracellular pathogen classified as a category
B biological agent by the Centers for Disease Control and Prevention. After respiratory …