Tuberculosis is still an urgent global health problem, mainly due to the spread of multi-drug
resistant M. tuberculosis strains, which lead to the need of new more efficient drugs. A …

A series of isoniazid derivatives bearing a phenolic or heteroaromatic coupled frame were
obtained by mechanochemical means. Their pH stability and their structural …

Host-derived fatty acids are an important carbon source for pathogenic mycobacteria during
infection. How mycobacterial cells regulate the catabolism of fatty acids to serve the …

Treatments for 'superbug'infections are the focus for innovative research, as drug resistance
threatens human health and medical practices globally. In particular, Acinetobacter …

A new set of molecules was designed and synthesized by compilation of pharmacologically
potential segments thiazole and quinoline bridged by 2-azetidinone as a linker in a single …

A series of twenty-five 2-azitidinone (β-lactam) derivatives were synthesized and evaluated
for anti-cancer properties against breast cancer, MCF-7 and MDA-MB-231. These β-lactam …

The ascent of polypharmacology in drug development has many implications for disease
therapy, most notably in the efforts of drug discovery, drug repositioning, precision medicine …

A new synthetic approach for realizing biologically relevant bis-aryl spiro [azetidine-2, 3′-
indoline]-2′, 4-diones was developed based on Staudinger ketene–imine cycloaddition …

The rise in antimicrobial resistance is a global health crisis and necessitates the
development of novel strategies to treat infections. For example, in 2022 tuberculosis (TB) …

In this work, we report an efficient approach to 2-oxoazetidine-3-carboxylic acid derivatives
based on a thermally promoted Wolff rearrangement of diazotetramic acids in the presence …