Candida Infections and Therapeutic Strategies: Mechanisms of Action for Traditional and Alternative Agents

GC de Oliveira Santos, CC Vasconcelos… - Frontiers in …, 2018 - frontiersin.org
The Candida genus comprises opportunistic fungi that can become pathogenic when the
immune system of the host fails. Candida albicans is the most important and prevalent …

Antifungals discovery: an insight into new strategies to combat antifungal resistance

AM Fuentefria, B Pippi, DF Dalla Lana… - Letters in applied …, 2018 - academic.oup.com
Undeniably, new antifungal treatments are necessary against pathogenic fungi. Fungal
infections have significantly increased in recent decades, being highlighted as important …

Impact of novel microbial secondary metabolites on the pharma industry

D Ramírez-Rendon, AK Passari, B Ruiz-Villafán… - Applied Microbiology …, 2022 - Springer
Microorganisms are remarkable producers of a wide diversity of natural products that
significantly improve human health and well-being. Currently, these natural products …

Synergistic combinations of antifungals and anti-virulence agents to fight against Candida albicans

J Cui, B Ren, Y Tong, H Dai, L Zhang - Virulence, 2015 - Taylor & Francis
Candida albicans, one of the pathogenic Candida species, causes high mortality rate in
immunocompromised and high-risk surgical patients. In the last decade, only one new class …

Antifungal Combinations against Candida Species: From Bench to Bedside

S Fioriti, L Brescini, F Pallotta, B Canovari, G Morroni… - Journal of Fungi, 2022 - mdpi.com
Candida spp. is the major causative agent of fungal infections in hospitalized patients and
the fourth most common cause of nosocomial bloodstream infection (BSI). The availability of …

Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells

K Wuputra, CC Ku, DC Wu, YC Lin, S Saito… - Journal of Experimental …, 2020 - Springer
Human pluripotent embryonic stem cells have two special features: self-renewal and
pluripotency. It is important to understand the properties of pluripotent stem cells and …

Synergistic interactions of sulfamethoxazole and azole antifungal drugs against emerging multidrug-resistant Candida auris

HE Eldesouky, X Li, NS Abutaleb, H Mohammad… - International journal of …, 2018 - Elsevier
Candida auris is an emerging multidrug-resistant pathogen implicated in numerous
outbreaks worldwide, with a notably high mortality rate (ca. 60%). A significant challenge …

Candida albicans Heat Shock Proteins and Hsps-Associated Signaling Pathways as Potential Antifungal Targets

Y Gong, T Li, C Yu, S Sun - Frontiers in cellular and infection …, 2017 - frontiersin.org
In recent decades, the incidence of invasive fungal infections has increased notably.
Candida albicans (C. albicans), a common opportunistic fungal pathogen that dwells on …

Antimicrobial Peptides: Avant-Garde Antifungal Agents to Fight against Medically Important Candida Species

GP Rodríguez-Castaño, F Rosenau, L Ständker… - Pharmaceutics, 2023 - mdpi.com
Expanding the antifungal drug arsenal for treating Candida infections is crucial in this era of
the rising life expectancy of patients with immunosuppression and comorbidities. Infections …

Potent synergistic interactions between lopinavir and azole antifungal drugs against emerging multidrug-resistant Candida auris

HE Eldesouky, EA Salama, NA Lanman… - Antimicrobial agents …, 2020 - Am Soc Microbiol
The limited therapeutic options and the recent emergence of multidrug-resistant Candida
species present a significant challenge to human medicine and underscore the need for …