The Hippo pathway: biology and pathophysiology
The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator
of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous …
of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous …
The Hippo signaling pathway in development and disease
The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction
has been implicated in an increasing number of human diseases, including cancer. Here …
has been implicated in an increasing number of human diseases, including cancer. Here …
Integration of Hippo-YAP signaling with metabolism
The Hippo-Yes-associated protein (YAP) signaling network plays a central role as an
integrator of signals that control cellular proliferation and differentiation. The past several …
integrator of signals that control cellular proliferation and differentiation. The past several …
[HTML][HTML] YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance
YAP1 is a transcriptional co-activator whose activity is controlled by the Hippo signaling
pathway. In addition to important functions in normal tissue homeostasis and regeneration …
pathway. In addition to important functions in normal tissue homeostasis and regeneration …
YAP inhibits ERα and ER+ breast cancer growth by disrupting a TEAD-ERα signaling axis
Hippo signaling restricts tissue growth by inhibiting the transcriptional effector YAP. Here we
uncover a role of Hippo signaling and a tumor suppressor function of YAP in estrogen …
uncover a role of Hippo signaling and a tumor suppressor function of YAP in estrogen …
Role of the Hippo pathway and mechanisms for controlling cellular localization of YAP/TAZ
H Kwon, J Kim, E Jho - The FEBS journal, 2022 - Wiley Online Library
The Hippo pathway is a crucial signaling mechanism that inhibits the growth of cells and
organs during development and in disease. When the Hippo pathway is activated, YAP/TAZ …
organs during development and in disease. When the Hippo pathway is activated, YAP/TAZ …
Hippo signalling during development
The Hippo signalling pathway and its transcriptional co-activator targets Yorkie/YAP/TAZ first
came to attention because of their role in tissue growth control. Over the past 15 years, it has …
came to attention because of their role in tissue growth control. Over the past 15 years, it has …
Molecular mechanism of hippo–YAP1/TAZ pathway in heart development, disease, and regeneration
X Chen, Y Li, J Luo, N Hou - Frontiers in physiology, 2020 - frontiersin.org
The Hippo–YAP1/TAZ pathway is a highly conserved central mechanism that controls organ
size through the regulation of cell proliferation and other physical attributes of cells. The …
size through the regulation of cell proliferation and other physical attributes of cells. The …
Hippo Signaling in Cancer: Lessons From Drosophila Models
K Snigdha, KS Gangwani, GV Lapalikar… - Frontiers in cell and …, 2019 - frontiersin.org
Hippo pathway was initially identified through genetic screens for genes regulating organ
size in fruitflies. Recent studies have highlighted the role of Hippo signaling as a key …
size in fruitflies. Recent studies have highlighted the role of Hippo signaling as a key …
The regulation of Yorkie, YAP and TAZ: new insights into the Hippo pathway
SA Manning, B Kroeger, KF Harvey - Development, 2020 - journals.biologists.com
The Hippo pathway is a highly conserved signalling pathway that regulates multiple
biological processes, including organ size control and cell fate. Since its discovery, genetic …
biological processes, including organ size control and cell fate. Since its discovery, genetic …