Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital
and ubiquitous phenomenon underlying the formation of membraneless organelles in …

Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …

Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

Mutations in the tumor suppressor SPOP (speckle-type POZ protein) cause prostate, breast,
and other solid tumors. SPOP is a substrate adaptor of the cullin3-RING ubiquitin ligase and …

Prostate cancer is the second most common cause of male cancer deaths in the United
States. However, the full range of prostate cancer genomic alterations is incompletely …

Cancer is a disease characterized by uncontrolled cell proliferation, but the precise
pathological mechanisms underlying tumorigenesis often remain to be elucidated. In recent …

Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most
prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides …

In the largest E3 ligase subfamily, Cul3 binds a BTB domain, and an associated protein-
interaction domain such as MATH recruits substrates for ubiquitination. Here, we present …

Prostate cancer (PCa) is one of the most commonly diagnosed malignancies and among the
leading causes of cancer-related death worldwide. It is a highly heterogeneous disease …

The ubiquitin-proteasome system (UPS) promotes the timely degradation of short-lived
proteins with key regulatory roles in a vast array of biological processes, such as cell cycle …