Morphogen gradients determine tissue pattern by triggering differential cell responses to
distinct morphogen concentrations. The strict quantitative dependence of the emerging …

EGF signaling is a well-known oncogenic pathway in animals. It is also a key developmental
pathway regulating terminal and dorsal-ventral patterning along with many other aspects of …

Here we describe a protocol for the fabrication and use of a microfluidic device to rapidly
orient> 700 Drosophila embryos in parallel for end-on imaging. The protocol describes …

Histone modifications are frequently used as markers for enhancer states, but how to
interpret enhancer states in the context of embryonic development is not clear. The poised …

Markers for the endoderm and mesoderm germ layers are commonly expressed together in
the early embryo, potentially reflecting cells' ability to explore potential fates before fully …

Patterning by morphogen gradients relies on the capacity to generate reproducible
distribution profiles. Morphogen spread depends on kinetic parameters, including diffusion …

The morphogen gradient of the transcription factor Dorsal in the early Drosophila embryo
has become one of the most widely studied tissue patterning systems. Dorsal is a …

Establishment of morphogen gradients in the early Drosophila embryo is challenged by a
diffusible extracellular milieu, and by rapid nuclear divisions that occur at the same time. To …

How natural variation in embryo size affects patterning of the Drosophila embryo dorsal–
ventral (DV) axis is not known. Here we examined quantitatively the relationship between …

Receptor Tyrosine Kinase (RTK) signaling pathways induce multiple biological responses,
often by regulating the expression of downstream genes. The HMG-box protein Capicua …