The skin microbiota represents an ecosystem composed of numerous microbial species
interacting with each other, as well as with host epithelial and immune cells. The microbiota …

Background Atopic dermatitis (AD, eczema) is driven by a combination of skin barrier
defects, immune dysregulation, and extrinsic stimuli such as allergens, irritants, and …

Core outcome sets are critically important outcomes that should be measured in clinical
trials. Their absence in atopic dermatitis is a form of research waste and impedes combining …

Atopic dermatitis (AD) is a complex multifactorial inflammatory skin disease that affects~ 280
million people worldwide. About 85% of AD cases begin in childhood, a significant portion of …

There is a tremendous need for accurate and reproducible scoring systems for the grading
of skin disease to further the development of research and standards of care. There are …

Background Atopic dermatitis (AD) is associated with eczematous lesions, pruritus, pain,
and sleep disturbance, which may negatively impact mental health over time. Objective To …

Background Multiple strategies have been used to evaluate the minimal important change
(MIC) of the Eczema Area and Severity Index (EASI) and Scoring Atopic Dermatitis …

Background Patients with atopic dermatitis (AD) have heterogeneous clinical phenotypes,
including different combinations of itch and lesional severity. Little is known about the …

Epidermal barrier dysfunction plays an important role in atopic dermatitis (AD). The difficulty
of objectively assessing AD severity and the introduction of new biologicals into clinical …

Background TREATgermany is a multicenter registry including patients with moderate‐to‐
severe atopic dermatitis (AD) from currently 74 study centers (university clinics, hospitals …