We review theory and empirical study of distress tolerance, an emerging risk factor
candidate for various forms of psychopathology. Despite the long-standing interest in and …

A reciprocal relationship exists between persistent pain and negative affective states such
as fear, anxiety, and depression. Accumulating evidence points to the amygdala as an …

Many children consider getting a needle to be one of their most feared and painful
experiences. Differentiating between a child's experience of fear and pain is critical to …

The amygdala is a structure of the temporal lobe thought to be involved in assigning
emotional significance to environmental information and triggering adapted physiological …

Substance use disorders (SUDs) manifest as chronic relapsing disorders, characterized by
compulsive drug taking despite serious adverse consequences, the loss of control over …

Background: Chronic insufficient sleep is a common finding in many pain-related and other
medical diseases and is frequently experienced in the general population. Prolonged …

Objective: Quantify the effect of thermal stressors on human performance. Background: Most
reviews of the effect of environmental stressors on human performance are qualitative. A …

BACKGROUND: Stress, one of the strongest risk factors for depression, has been linked to
“anhedonic” behavior and dysfunctional reward-related neural circuitry in preclinical models …

The effect of emotions on pain perception is generally recognized but the underlying
mechanisms remain unclear. Here, emotions related to pain were induced in healthy …

Chronic low back pain (cLBP) has a tremendous personal and socioeconomic impact, yet
the underlying pathology remains a mystery in the majority of cases. An objective measure …