Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

Carbohydrates (glycans, saccharides, sugars) are everywhere. In fact, glycan–protein
interactions are involved in many essential processes of life and disease. The …

Respiratory syncytial virus (RSV) infection is a major cause of severe lower respiratory tract
infection and death in young infants and the elderly. With no effective prophylactic treatment …

Monoclonal antibodies (mAbs) are currently the largest and fastest growing class of
biopharmaceuticals, and they address unmet medical needs, eg, in oncology and in auto …

Immune checkpoints are the crucial regulators of immune system and play essential roles in
maintaining self-tolerance, preventing autoimmune responses, and minimizing tissue …

Immunoglobulin G (IgG) antibodies are post-translationally modified by the addition of
complex carbohydrate molecules–glycans, which have profound effects on the IgG function …

Multiple factors influence immunoglobulin G glycosylation, which in turn affect the
glycoproteins' function on eliciting an anti-inflammatory or pro-inflammatory response. It is …

Antibodies to Ebola virus glycoprotein (EBOV GP) represent an important correlate of the
vaccine efficiency and infection survival. Both neutralization and some of the Fc-mediated …

Monoclonal antibody (mAb)-based therapeutics are the fastest growing class of human
pharmaceuticals. They are typically IgG1 molecules with N-glycans attached to the N297 …

The immune system is strictly regulated by glycosylation through the addition of highly
diverse and dynamically changing sugar structures (glycans) to the majority of immune cell …