A central goal of neuroscience research is to understand how experiences modify brain
circuits to guide future adaptive behavior. In response to environmental stimuli, neural circuit …

While neurotransmitter identity was once considered singular and immutable for mature
neurons, it is now appreciated that one neuron can release multiple neuroactive substances …

Dysfunctional memory seems to be a key component of diverse dementias and other
neuropsychiatric disorders; unfortunately, no effective treatment exists for this, probably …

Abstract microRNAs (miRs) are fundamental regulators of protein coding genes. In the CNS,
miR-9 is highly enriched and critical for neuronal development and function. Mature miRs …

Activity-dependent local protein synthesis is critical for synapse-specific, persistent plasticity.
Abnormalities in local protein synthesis have been implicated in psychiatric disorders. We …

Vascular stiffness plays a key role in the pathogenesis of hypertension. Recent studies
indicate that the age-associated reduction in miR-181b levels in vascular smooth muscle …

The discovery of the microRNA system has revolutionized our understanding of translational
control. Furthermore, growing appreciation of the pivotal role that de novo translation plays …

Activity-dependent synaptic plasticity involves rapid regulation of neuronal protein synthesis
on a time-scale of minutes. miRNA function in synaptic plasticity and memory formation has …

Translin-associated protein X (TSNAX), also called trax, was first identified as a protein that
interacts with translin. Subsequent studies demonstrated that these proteins form a …

Large artery stiffness (LAS) is a major, independent risk factor underlying cardiovascular
disease that increases with aging. The emergence of microRNA signaling as a key regulator …