Environmental challenges are part of daily life for any individual. In fact, stress appears to be
increasingly present in our modern, and demanding, industrialized society. Virtually every …

The hypothalamo–pituitary–adrenal (HPA) axis represents a complex neuroendocrine
feedback loop controlling the secretion of adrenal glucocorticoid hormones. Central to its …

The primary adrenal cortical steroid hormones, aldosterone, and the glucocorticoids cortisol
and corticosterone, act through the structurally similar mineralocorticoid (MR) and …

Stress and glucocorticoid hormones regulate hippocampal neurogenesis, but the molecular
mechanisms underlying their effects are unknown. We, therefore, investigated the molecular …

Glucocorticoids play an important biphasic role in modulating neural plasticity; low doses
enhance neural plasticity and spatial memory behavior, whereas chronic, higher doses …

It is now broadly accepted that psychological stress may change the internal homeostatic
state of an individual. During acute stress, adaptive physiological responses occur, which …

Corticosteroid hormones, released during stressful encounters, have profound and far-
reaching effects on cognition. They are often thought to accomplish these effects primarily …

Stress is defined as a state of perturbed homeostasis following endangerment that evokes
manifold adaptive reactions, which are summarized as the stress response. In the case of …

There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

Depression is one of the most prevalent and life-threatening forms of mental illnesses,
whereas Alzheimer's disease is a neurodegenerative disorder that affects more than 37 …