The calibrated application of limited-duration, cyclic, moderately intense hypoxia-
reoxygenation increases cardiac resistance to ischemia-reperfusion stress. These …

Since a constant supply of oxygen is essential to sustain life, organisms have evolved
multiple defence mechanisms to ensure maintenance of the delicate balance between …

Increasing evidence indicates that stimulating hippocampal neurogenesis could provide
novel avenues for the treatment of depression, and recent studies have shown that in vitro …

It has been documented that reactive oxygen species (ROS) contribute to oxidative stress,
leading to diseases such as ischemic heart disease. Recently, increasing evidence has …

Mitochondria are indispensable for bioenergetics and for the regulation of physiological/
signaling events in cellular life. Although TNF-α-induced oxidative stress and mitochondrial …

Objective: Brief systemic hypoxia protects the rodent brain from subsequent ischemic injury,
although the protection wanes within days. We hypothesized that the duration of ischemic …

This review deals with the capability of the heart to adapt to chronic hypoxia in animals
exposed to either natural or simulated high altitude. From the broad spectrum of related …

Enhanced reactive oxygen species (ROS) at the beginning of reperfusion activated signal
transducer and activator of transcription 3 (STAT3) in intermittent hypobaric hypoxia (IHH) …

Although acute myocardial infarction is one of the most common fatal diseases worldwide,
the understanding of its underlying pathogenesis continues to develop. Myocardial …

In the past two decades, Chile has developed intense mining activity in the Andes mountain
range, whose altitude is over 4,000 meters above sea level. It is estimated that a workforce …