Microbial production of natural and non-natural flavonoids: pathway engineering, directed evolution and systems/synthetic biology

RP Pandey, P Parajuli, MAG Koffas, JK Sohng - Biotechnology advances, 2016 - Elsevier
In this review, we address recent advances made in pathway engineering, directed
evolution, and systems/synthetic biology approaches employed in the production and …

Research progress, challenges, and perspectives in microbial pigment production for industrial applications-A review

LJ Rather, SS Mir, SA Ganie, Q Li - Dyes and Pigments, 2023 - Elsevier
Microbial pigments are gaining more attention in recent times due to their versatile
applications in the pharmaceutical, food, cosmetic, and textile industries. The development …

基于花青素苷合成和呈色机理的观赏植物花色改良分子育种

戴思兰, 洪艳 - 中国农业科学, 2016 - chinaagrisci.com
Flower color, one of the most important quality traits for ornamental plants, is of great
adaptive significance during the natural evolution process of plants. Moreover, flower color …

Strain Improvement of Recombinant Escherichia coli for Efficient Production of Plant Flavonoids

E Leonard, Y Yan, ZL Fowler, Z Li, CG Lim… - Molecular …, 2008 - ACS Publications
Plant flavonoid polyphenols continue to find increasing pharmaceutical and nutraceutical
applications; however their isolation, especially of pure compounds, from plant material …

Improving NADPH availability for natural product biosynthesis in Escherichia coli by metabolic engineering

JA Chemler, ZL Fowler, KP McHugh, MAG Koffas - Metabolic engineering, 2010 - Elsevier
With microbial production becoming the primary choice for natural product synthesis,
increasing precursor and cofactor availability has become a chief hurdle for the generation …

Improvement of catechin production in Escherichia coli through combinatorial metabolic engineering

S Zhao, JA Jones, DM Lachance, N Bhan, O Khalidi… - Metabolic …, 2015 - Elsevier
Reconstruction of highly efficient biosynthesis pathways is essential for the production of
valuable plant secondary metabolites in recombinant microorganisms. In order to improve …

Engineering de novo anthocyanin production in Saccharomyces cerevisiae

M Levisson, C Patinios, S Hein, PA de Groot… - Microbial cell …, 2018 - Springer
Background Anthocyanins are polyphenolic pigments which provide pink to blue colours in
fruits and flowers. There is an increasing demand for anthocyanins, as food colorants and as …

High‐yield anthocyanin biosynthesis in engineered Escherichia coli

Y Yan, Z Li, MAG Koffas - Biotechnology and bioengineering, 2008 - Wiley Online Library
Anthocyanins are red, purple, or blue plant water‐soluble pigments. In the past two decades,
anthocyanins have received extensive studies for their anti‐oxidative, anti‐inflammatory, anti …

Enhancing Flavan-3-ol Biosynthesis in Saccharomyces cerevisiae

C Sun, G Li, H Li, Y Lyu, S Yu… - Journal of Agricultural and …, 2021 - ACS Publications
Flavan-3-ols are a group of flavonoids that exert beneficial effects. This study aimed to
enhance key metabolic processes related to flavan-3-ols biosynthesis. The engineered …

Biosynthesis and regulation of flavonoids in buckwheat

K Matsui, AR Walker - Breeding science, 2020 - jstage.jst.go.jp
Buckwheat contains an abundance of antioxidants such as polyphenols and is considered a
functional food. Among polyphenols, flavonoids have multiple functions in various aspects of …