Recombinant therapeutic proteins (RTPs) are important parts of biopharmaceuticals.
Chinese hamster ovary cells (CHO) have become the main cell hosts for the production of …

In biopharmaceutical production, Chinese hamster ovary (CHO) cells derived from
Cricetulus griseus remain the most commonly used host cell for recombinant protein …

Biomarkers are valuable tools in clinical research where they allow to predict susceptibility
to diseases, or response to specific treatments. Likewise, biomarkers can be extremely …

A new area of focus in Chinese hamster ovary (CHO) biotechnology is the role of small
(exosomes) and large (microvesicles or microparticles) extracellular vesicles (EVs). CHO …

Abstract miRNAs are potent molecular regulators of cellular behaviour. The manipulation of
these small non-coding RNAs has been used to enhance industrially relevant phenotypes in …

CHO cells are extensively employed in biological drug industry to manufacture therapeutic
proteins. Nevertheless, production of biopharmaceuticals faces obstacles such as limited …

Industrial manufacturing of high-value biopharmaceuticals is dominated by mammalian
cells. Advances in mammalian cell engineering have paved the way for remarkable …

It is widely accepted that the growing demand for recombinant therapeutic proteins has led
to the expansion of the biopharmaceutical industry and the development of strategies to …

The ability to produce recombinant proteins by utilizing different “cell factories”
revolutionized the biotherapeutic and pharmaceutical industry. Chinese hamster ovary …

Sodium butyrate (NaBu) is an efficient supplement for increasing recombinant protein
production in Chinese hamster ovary (CHO) cell culture. To elucidate the effects of NaBu on …