The 18 kDa translocator protein (TSPO) is a highly conserved protein located in the outer
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …

The translocator protein (TSPO) is an outer mitochondrial membrane protein that is widely
used as a biomarker of neuroinflammation, being markedly upregulated in activated …

Microglial phagocytosis is an energetically demanding process that plays a critical role in
the removal of toxic protein aggregates in Alzheimer's disease (AD). Recent evidence …

Translocator protein (TSPO), also known as peripheral benzodiazepine receptor, is a
transmembrane protein located on the outer mitochondria membrane (OMM) and mainly …

Glial cells play critical roles in the normal development and function of neural circuits, but in
many neurodegenerative diseases, they become dysregulated and may contribute to the …

Efficient treatment of stress-related disorders, such as depression, is still a major challenge.
The onset of antidepressant drug action is generally quite slow, while the anxiolytic action of …

TSPO is mainly expressed in the mitochondrial outer membrane of microglia in the central
nervous system, and its expression is greatly increased when microglia are activated …

Simple Summary The translocator protein (TSPO) has been under extensive investigation as
a specific marker in positron emission tomography (PET) to visualize brain lesions following …

Aberrant immune responses including reactive phagocytes are implicated in the etiology of
age-related macular degeneration (AMD), a major cause of blindness in the elderly. The …

Translocator protein (TSPO, 18 kDa) is an evolutionary, well-preserved, and tryptophan-rich
169-amino-acid protein which localizes on the contact sites between the outer and inner …