Morpholine, a six-membered heterocycle containing one nitrogen and one oxygen atom, is a
moiety of great significance. It forms an important intermediate in many industrial and …

Therapeutic applications of nuclease-based genome editing would benefit from improved
methods for transgene integration via homology-directed repair (HDR). To improve HDR …

Oxazines have brought much synthetic interest due to their extensive biological activities.
These are the important category of heterocycles, which may be formally derived from …

DNA double-strand break (DSB) is considered the most deleterious type of DNA damage,
which is generated by ionizing radiation (IR) and a subset of anticancer drugs. DNA …

The deployment of DNA damage response (DDR) combats various forms of DNA damage,
ensuring genomic stability. Cancer cells' propensity for genomic instability offers therapeutic …

Abstract Phosphatidylinositol 3-kinase (PI3K) is a pivotal regulator of intracellular signaling
pathways and considered as a promising target in the development of a therapeutic …

Innovative, efficient, clean, experimentally simple and environmentally friendly one-pot
biocatalytic synthesis of two small libraries of 3, 4-dihydro-2 (1H)-quinoxalinones (4a–m) …

Tfcp2l1 can maintain mouse embryonic stem cell (mESC) self-renewal. However, it remains
unknown how Tfcp2l1 protein stability is regulated. Here, we demonstrate that β-transducin …

Background Overcoming taxane resistance remains a major clinical challenge in metastatic
castrate‐resistant prostate cancer (mCRPC). Loss of DNA repair proteins is associated with …

Abstract Topoisomerase II (TOP2)-targeting anticancer chemotherapeutic drugs, termed
TOP2 poisons, are widely used and effective in the clinic by stabilizing TOP2-DNA covalent …