Prions are defined as infectious agents that comprise only proteins and are responsible for
transmissible spongiform encephalopathies (TSEs)–fatal neurodegenerative diseases that …

Prion diseases are transmissible neurodegenerative disorders affecting humans and
animals for which no therapeutic or prophylactic regimens exist. During the last three years …

Prion diseases are fatal neurodegenerative and infectious disorders for which no
therapeutic or prophylactic regimens exist. In search of cellular mechanisms that play a role …

Highlights•Prions are misfolded proteins causing fatal neurodegenerative
diseases.•Autophagy dictates the fate of PrP Sc in various contexts in prion …

The conversion of the cellular prion protein (PrP c) into pathologic PrP Sc and the
accumulation of aggregated PrP Sc are hallmarks of prion diseases. A variety of …

Accumulation of PrPSc, an insoluble and protease-resistant pathogenic isoform of the
cellular prion protein (PrPC), is a hallmark in prion diseases. Branched polyamines …

Transmissible spongiform encephalopathies, including variant-Creutzfeldt-Jakob disease
(vCJD) in humans and bovine spongiform encephalopathies in cattle, are fatal …

Prion diseases are fatal infectious neurodegenerative disorders in human and animals
caused by misfolding of the cellular prion protein (PrP C) into the pathological isoform PrP …

Prion diseases are fatal transmissible neurodegenerative disorders that affect animals and
humans. Prions are proteinaceous infectious particles consisting of a misfolded isoform of …

Prions cause fatal infectious neurodegenerative diseases in humans and animals. Cell
culture models are essential for studying the molecular biology of prion propagation …