The increasing interest in the Mediterranean diet hinges on its healthy and anti-ageing
properties. The composition of fatty acids, vitamins and polyphenols in olive oil, a key …

Mechanistic/mammalian target of rapamycin (mTOR) belongs to the phosphatidylinositol
kinase-related kinase (PIKK) family. mTOR signaling is required for the commencement of …

Introduction: Clinical trials and population studies indicate the healthy virtues of the
Mediterranean diet and its main lipid component, extra-virgin olive oil (EVOO). Olive leaves …

Objective: Mild cognitive impairment (MCI) is a cognitive syndrome in the elderly individuals.
MCI drug treatment is still under debate. On the other hand, MCI progress is higher in people …

There is emerging evidence that cognitive impairment could be a diabetes mellitus-related
complication. It has been suggested that diabetic people are at increased risk of cognitive …

Although type 2 diabetes is a well-known risk factor for Alzheimer's disease (AD), little is
known about how its precursor—prediabetes—impacts neuropsychological function and …

Increased risks for Alzheimer's disease (AD) are a well-recognized consequence of
diabetes, insulin resistance (IR), and hyperinsulinemia. Since cerebrospinal fluid (CSF) is …

The amyloid-β (Aβ) oligomer hypothesis of Alzheimer's disease (AD) still dominates the field,
yet the clinical trial evidence does not robustly support it. A falsifiable prediction of the …

In Japan, the prevalence of dementia is expected to reach 4.7 million by 2025. This study
aimed to develop a risk score for the prediction of incident dementia in community-dwelling …

The voltage-gated potassium (Kv) channel blockers tetraethylammonium (TEA) and 4-
aminopyridine (4-AP) have shown beneficial effects on some neurological disorders. But …