The past decade has seen an explosion of research directed toward better understanding of
the mechanisms of mesenchymal stem/stromal cell (MSC) function during rescue and repair …

Microvesicles (MVs) are circular fragments of membrane released from the endosomal
compartment as exosomes or shed from the surface membranes of most cell types. An …

Fibrosis is caused by extensive deposition of extracellular matrix (ECM) components, which
play a crucial role in injury repair. Fibrosis attributes to~ 45% of all deaths worldwide. The …

Sepsis is a severe and dysregulated inflammatory response to infection characterized by
end-organ dysfunction distant from the primary site of infection. Development of acute kidney …

Among the various types of cell-to-cell signaling, paracrine signaling comprises those
signals that are transmitted over short distances between different cell types. In the human …

Mesenchymal stem (stromal) cells (MSCs) have potent anti‐inflammatory/
immunosuppressive properties which underlie much of their therapeutic potential. This fact …

Allogeneic mesenchymal stem or stromal cells (MSCs) are proposed as cell therapies for
degenerative, inflammatory, and autoimmune diseases. The feasibility of allogeneic MSC …

The paracrine theory has recently changed the view of the biological action of stem cells and
of the subsequent potential application of stem cells in regenerative medicine. Indeed, most …

Aims: Several studies have demonstrated administration of mesenchymal stem cells (MSC)
could reverse kidney injury by paracrine mechanisms rather than by MSC …

Critically ill patients often suffer from multiple organ failures involving lung, kidney, liver or
brain. Genomic, proteomic and metabolomic approaches highlight common injury …