NK cell-based immune checkpoint inhibition
Immunotherapy, with an increasing number of therapeutic dimensions, is becoming an
important mode of treatment for cancer patients. The inhibition of immune checkpoints …
important mode of treatment for cancer patients. The inhibition of immune checkpoints …
[HTML][HTML] The promising immune checkpoint LAG-3: from tumor microenvironment to cancer immunotherapy
L Long, X Zhang, F Chen, Q Pan… - Genes & …, 2018 - ncbi.nlm.nih.gov
Cancer immunotherapy and tumor microenvironment have been at the forefront of research
over the past decades. Targeting immune checkpoints especially programmed death 1 (PD …
over the past decades. Targeting immune checkpoints especially programmed death 1 (PD …
The next-generation immune checkpoint LAG-3 and its therapeutic potential in oncology: third time'sa charm
Q Lecocq, M Keyaerts, N Devoogdt… - International journal of …, 2020 - mdpi.com
The blockade of immune checkpoints (ICPs), such as cytotoxic T lymphocyte associated
protein-4 (CTLA-4) and programmed death-1 (PD-1) and its ligand (PD-L1), has propelled …
protein-4 (CTLA-4) and programmed death-1 (PD-1) and its ligand (PD-L1), has propelled …
Unleashing natural killer cells in the tumor microenvironment–the next generation of immunotherapy?
A Ben-Shmuel, G Biber, M Barda-Saad - Frontiers in immunology, 2020 - frontiersin.org
The emergence of immunotherapy for cancer treatment bears considerable clinical promise.
Nevertheless, many patients remain unresponsive, acquire resistance, or suffer dose …
Nevertheless, many patients remain unresponsive, acquire resistance, or suffer dose …
The common cytokine receptor γ chain family of cytokines
JX Lin, WJ Leonard - Cold Spring Harbor perspectives in …, 2018 - cshperspectives.cshlp.org
Interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 form a family of cytokines based on their
sharing the common cytokine receptor γ chain (γc), which was originally discovered as the …
sharing the common cytokine receptor γ chain (γc), which was originally discovered as the …
Inhibitory receptors and immune checkpoints regulating natural killer cell responses to cancer
I Buckle, C Guillerey - Cancers, 2021 - mdpi.com
Simple Summary Recent years marked the discovery and increased understanding of the
role immune checkpoints play in immunity against cancer. This has revolutionized cancer …
role immune checkpoints play in immunity against cancer. This has revolutionized cancer …
The role of the cytoskeleton in regulating the natural killer cell immune response in health and disease: from signaling dynamics to function
A Ben-Shmuel, B Sabag, G Biber… - Frontiers in cell and …, 2021 - frontiersin.org
Natural killer (NK) cells are innate lymphoid cells, which play key roles in elimination of
virally infected and malignant cells. The balance between activating and inhibitory signals …
virally infected and malignant cells. The balance between activating and inhibitory signals …
CRISPR-Cas9–mediated TIM3 knockout in human natural killer cells enhances growth inhibitory effects on human Glioma cells
T Morimoto, T Nakazawa, R Matsuda… - International journal of …, 2021 - mdpi.com
Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in
adults. Natural Killer (NK) cells are potent cytotoxic effector cells against tumor cells inducing …
adults. Natural Killer (NK) cells are potent cytotoxic effector cells against tumor cells inducing …
Understanding immunoactinopathies: A decade of research on WAS gene defects
RC Vieira, LG Pinho… - Pediatric Allergy and …, 2023 - Wiley Online Library
Immunoactinopathies caused by mutations in actin‐related proteins are a growing group of
inborn errors of immunity (IEI). Immunoactinopathies are caused by a dysregulated actin …
inborn errors of immunity (IEI). Immunoactinopathies are caused by a dysregulated actin …
IL-2 mediates NK cell proliferation but not hyperactivity
Natural killer cells play a major role in innate immunity against tumor and virus-infected
cells. NK cells express activating and inhibitory receptors to regulate their function. It has …
cells. NK cells express activating and inhibitory receptors to regulate their function. It has …