Organoids are 3D cell culture systems that mimic some of the structural and functional
characteristics of an organ. Organoid cultures provide the opportunity to study organ-level …

The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Environmental factors are the largest contributors to cardiovascular disease. Here we show
that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated …

Mechanical hallmarks of fibrotic microenvironments are both outcomes and causes of
fibrosis progression. Understanding how cells sense and transmit mechanical cues in the …

Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …

Fibroblasts produce and turn over collagenous extracellular matrix as part of the normal
adaptive response to increased mechanical load in the heart, eg during prolonged exercise …

Tissue engineering has enabled the development of advanced and physiologically relevant
models of cardiovascular diseases, with advantages over conventional 2D in vitro assays …

The role of pathological angiogenesis on liver fibrogenesis is still unknown. Here, we
developed fibrotic microniches (FμNs) that recapitulate the interaction of liver sinusoid …

Cardiac fibrosis is one of the major components of the healing mechanism following any
injury of the heart and as such may contribute to both systolic and diastolic dysfunction in a …

Heart disease is a significant burden on global health care systems and is a leading cause
of death each year. To improve our understanding of heart disease, high quality disease …