Juvenile idiopathic arthritis

A Martini, DJ Lovell, S Albani, HI Brunner… - Nature Reviews …, 2022 - nature.com
Juvenile idiopathic arthritis (JIA) is an umbrella term for arthritis of unknown origin, lasting
for> 6 weeks with onset before 16 years of age. JIA is the most common chronic …

The IL-1 family of cytokines and receptors in rheumatic diseases

CA Dinarello - Nature Reviews Rheumatology, 2019 - nature.com
More than any other cytokine family, the 11 members of the IL-1 family are associated with
innate immune responses, which occur in acute inflammation and chronic inflammatory …

Toward new classification criteria for juvenile idiopathic arthritis: first steps, pediatric rheumatology international trials organization international consensus

A Martini, A Ravelli, T Avcin, MW Beresford… - The Journal of …, 2019 - jrheum.org
Objective. To revise the current juvenile idiopathic arthritis (JIA) International League of
Associations for Rheumatology (ILAR) classification criteria with an evidence-based …

Mechanisms, biomarkers and targets for adult-onset Still's disease

E Feist, S Mitrovic, B Fautrel - Nature Reviews Rheumatology, 2018 - nature.com
Adult-onset Still's disease (AoSD) is a rare but clinically well-known, polygenic, systemic
autoinflammatory disease. Owing to its sporadic appearance in all adult age groups with …

Monogenic autoinflammatory disorders: conceptual overview, phenotype, and clinical approach

PA Nigrovic, PY Lee, HM Hoffman - Journal of Allergy and Clinical …, 2020 - Elsevier
Autoinflammatory diseases are conditions in which pathogenic inflammation arises primarily
through antigen-independent hyperactivation of immune pathways. First recognized just …

Immune cartography of macrophage activation syndrome in the COVID-19 era

D McGonagle, AV Ramanan… - Nature Reviews …, 2021 - nature.com
A hyperinflammatory 'cytokine storm'state termed macrophage activation syndrome (MAS),
culminating from a complex interplay of genetics, immunodeficiency, infectious triggers and …

Biological classification of childhood arthritis: roadmap to a molecular nomenclature

PA Nigrovic, RA Colbert, VM Holers, S Ozen… - Nature reviews …, 2021 - nature.com
Chronic inflammatory arthritis in childhood is heterogeneous in presentation and course.
Most forms exhibit clinical and genetic similarity to arthritis of adult onset, although at least …

Severe delayed hypersensitivity reactions to IL-1 and IL-6 inhibitors link to common HLA-DRB1* 15 alleles

VE Saper, MJ Ombrello, AH Tremoulet… - Annals of the …, 2022 - ard.bmj.com
Objectives Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe,
delayed hypersensitivity reaction (DHR). We observed DRESS to inhibitors of interleukin 1 …

[图书][B] Textbook of pediatric rheumatology

RE Petty, RM Laxer, CB Lindsley, L Wedderburn… - 2020 - books.google.com
Offering up-to-date, comprehensive coverage of disease progression, diagnosis,
management, and prognosis, Textbook of Pediatric Rheumatology is the definitive reference …

Systemic juvenile idiopathic arthritis

JJY Lee, R Schneider - Pediatric Clinics, 2018 - pediatric.theclinics.com
Systemic juvenile idiopathic arthritis (sJIA) is a very distinctive subtype of juvenile idiopathic
arthritis (JIA) with unique clinical manifestations, associated complications, and therapeutic …