Since its first isolation in 1934, hyaluronic acid (HA) has been studied across a variety of
research areas. This unbranched glycosaminoglycan consisting of repeating disaccharide …

Hyaluronic acid (HA) is a natural polysaccharide with good biocompatibility and
degradability. HA and its derivatives can be used as sustained-release carriers for drugs …

Objective Sudden hearing loss is a frightening symptom that often prompts an urgent or
emergent visit to a health care provider. It is frequently but not universally accompanied by …

Epithelial surfaces protect exposed tissues in the body against intrusion of foreign materials,
including xenobiotics, pollen and microbiota. The relative permeability of the various …

Liposomes have been used extensively as micro-and nanocarriers for hydrophobic or
hydrophilic molecules. However, conventional liposomes are biodegradable and quickly …

The least damaging and most economical method to deliver drugs or carriers into the inner
ear for treatment of disease is through the middle ear. However, the retention of drug in the …

Drug delivery is a rapidly growing area of research motivated by the nanotechnology
revolution, the ideal of personalized medicine, and the desire to reduce the side effects of …

The prevalence of ear disorders has spurred efforts to develop drug delivery systems to treat
these conditions. Here, recent advances in drug delivery systems that access the ear …

Objectives The treatment of inner ear disorders remains challenging due to anatomic
barriers intrinsic to the bony labyrinth. The purpose of this review is to highlight recent …

Most therapies for treating sensorineural hearing loss are challenged by the delivery across
multiple tissue barriers to the hard-to-access anatomical location of the inner ear. In this …