Natural products (NPs) are primarily recognized as privileged structures to interact with
protein drug targets. Their unique characteristics and structural diversity continue to marvel …

Natural products (NPs) produced by microorganisms and plants are a major source of drugs,
herbicides, and fungicides. Thanks to recent advances in DNA sequencing, bioinformatics …

Covering: 2000 to 2020 Machine learning (ML) is an efficient tool for the prediction of
bioactivity and the study of structure–activity relationships. Over the past decade, an …

Intestinal organoids have emerged as the new paradigm for modelling the healthy and
diseased intestine with patient-relevant properties. In this study, we show directed …

Cell cultures are widely used in pharmaceutical, medical, food/nutrition and biological
sciences. In food and nutrition science, intestinal cell culture models of human origin are …

The popular murine macrophage cell line, RAW 264.7, is often used to initially screen
natural products for bioactivity and to predict their potential effect in vivo or on primary cells …

Abstract A new series of 4-(3-nitrophenyl) thiazol-2-ylhydrazone derivatives were designed,
synthesised, and evaluated to assess their inhibitory effect on the human monoamine …

Highlights•Natural products are an important source of therapeutic compounds.•Natural
product research can benefit greatly from advances in AI.•Knowledge integration is a limiting …

Constant research on natural products has generated, over time, a large number of
compounds with the potential to be evaluated in several biological tests and subsequently …

Introduction: Molecular topology (MT) has emerged in recent years as a powerful approach
for the in silico generation of new drugs. In the last decade, its application has become more …