Sarcoma subtype classification is currently mainly based upon histopathological
morphology. Molecular analyses have emerged as an efficient addition to the diagnostic …

Undifferentiated pleomorphic sarcoma now falls under the broader rubric of undifferentiated
soft tissue sarcoma (USTS) in the 2020 World Health Organization classification of bone and …

Microenvironment-driven tumor heterogeneity causes the limitation of immunotherapy of
sarcomas. Nonetheless, systematical studies of various molecular levels can enhance the …

Background Soft tissue sarcoma, a malignant tumor arising from mesenchymal tissues with
poor prognosis. 5′-Nucleotidase Domain Containing 2 (NT5DC2) is a novel oncogene …

As a high-grade soft-tissue sarcoma (STS), undifferentiated pleomorphic sarcoma (UPS) is
highly recurrent and malignant. UPS is categorized as a tumor of uncertain differentiation …

MALDI mass spectrometry imaging (MALDI imaging) uniquely advances cancer research, by
measuring spatial distribution of endogenous and exogenous molecules directly from tissue …

Background: Sarcomas are heterogeneous rare malignancies constituting approximately
1% of all solid cancers in adults and including more than 70 histological and molecular …

Due to the rarity and heterogeneity, it is challenging to explore and develop new therapeutic
targets for patients with sarcoma. Recently, immune cell infiltration in the tumor …

Sarcomas is a complex group of malignant diseasse with undetermined molecular
mechanisms. Receptor interacting serine/threonine kinase 3 (RIPK3) is a necroptosis‑and …

In order to characterise soft tissue tumours, pathologists often utilise specialised additional
tests, or may seek opinions from subspecialist pathologists due to rarity or complex …