[HTML][HTML] Recent advances in metabolomics analysis for early drug development

JC Alarcon-Barrera, S Kostidis, A Ondo-Mendez… - Drug discovery today, 2022 - Elsevier
Highlights•Metabolomics has become a widely applied tool in drug development.•
Metabolomics plays a key role for the identification of physiological response markers.• …

[HTML][HTML] Toward building mass spectrometry-based metabolomics and lipidomics atlases for biological and clinical research

S Rakusanova, O Fiehn, T Cajka - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Current metabolomics and lipidomics studies are limited in the number of examined
matrices, the breadth and scope of methods, reporting the number of metabolites, and data …

Dynamic lipidome alterations associated with human health, disease and ageing

D Hornburg, S Wu, M Moqri, X Zhou, K Contrepois… - Nature …, 2023 - nature.com
Lipids can be of endogenous or exogenous origin and affect diverse biological functions,
including cell membrane maintenance, energy management and cellular signalling. Here …

Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome

B Walitt, K Singh, SR LaMunion, M Hallett… - Nature …, 2024 - nature.com
Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a
disabling disorder, yet the clinical phenotype is poorly defined, the pathophysiology is …

[HTML][HTML] Advances in high throughput LC/MS based metabolomics: A review

RS Plumb, LA Gethings, PD Rainville, G Isaac… - TrAC Trends in …, 2023 - Elsevier
Properly implemented, metabolic and lipidomic profiling can provide a deeper
understanding of mammalian, plant and bacterial biology. These omics-tools have …

[HTML][HTML] Recent advances towards mass spectrometry-based clinical lipidomics

S Salihovic, S Lamichane, T Hyötyläinen… - Current opinion in …, 2023 - Elsevier
The objective of this review is to provide a comprehensive summary of the latest
methodological advancements and emerging patterns in utilizing lipidomics in clinical …

[HTML][HTML] Pre-analytical sample handling standardization for reliable measurement of metabolites and lipids in LC-MS-based clinical research

A Sens, S Rischke, L Hahnefeld, E Dorochow… - Journal of Mass …, 2023 - Elsevier
The emerging disciplines of lipidomics and metabolomics show great potential for the
discovery of diagnostic biomarkers, but appropriate pre-analytical sample-handling …

Trip13 depletion in liver cancer induces a lipogenic response contributing to Plin2‐dependent mitotic cell death

M Rios Garcia, B Meissburger, J Chan… - Advanced …, 2022 - Wiley Online Library
Aberrant energy metabolism and cell cycle regulation both critically contribute to malignant
cell growth and both processes represent targets for anticancer therapy. It is shown here that …

[HTML][HTML] Development of a targeted hydrophilic interaction liquid chromatography-tandem mass spectrometry based lipidomics platform applied to a coronavirus …

Z Zhang, M Singh, A Kindt, AB Wegrzyn… - … of Chromatography A, 2023 - Elsevier
The importance of lipids seen in studies of metabolism, cancer, the recent COVID-19
pandemic and other diseases has brought the field of lipidomics to the forefront of clinical …

Omic-scale high-throughput quantitative LC–MS/MS approach for circulatory lipid phenotyping in clinical research

J Medina, R Borreggine, T Teav, L Gao, S Ji… - Analytical …, 2023 - ACS Publications
Lipid analysis at the molecular species level represents a valuable opportunity for clinical
applications due to the essential roles that lipids play in metabolic health. However, a …