[HTML][HTML] Recent advances in metabolomics analysis for early drug development
JC Alarcon-Barrera, S Kostidis, A Ondo-Mendez… - Drug discovery today, 2022 - Elsevier
Highlights•Metabolomics has become a widely applied tool in drug development.•
Metabolomics plays a key role for the identification of physiological response markers.• …
Metabolomics plays a key role for the identification of physiological response markers.• …
[HTML][HTML] Toward building mass spectrometry-based metabolomics and lipidomics atlases for biological and clinical research
Current metabolomics and lipidomics studies are limited in the number of examined
matrices, the breadth and scope of methods, reporting the number of metabolites, and data …
matrices, the breadth and scope of methods, reporting the number of metabolites, and data …
Dynamic lipidome alterations associated with human health, disease and ageing
Lipids can be of endogenous or exogenous origin and affect diverse biological functions,
including cell membrane maintenance, energy management and cellular signalling. Here …
including cell membrane maintenance, energy management and cellular signalling. Here …
Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome
B Walitt, K Singh, SR LaMunion, M Hallett… - Nature …, 2024 - nature.com
Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a
disabling disorder, yet the clinical phenotype is poorly defined, the pathophysiology is …
disabling disorder, yet the clinical phenotype is poorly defined, the pathophysiology is …
[HTML][HTML] Advances in high throughput LC/MS based metabolomics: A review
Properly implemented, metabolic and lipidomic profiling can provide a deeper
understanding of mammalian, plant and bacterial biology. These omics-tools have …
understanding of mammalian, plant and bacterial biology. These omics-tools have …
[HTML][HTML] Recent advances towards mass spectrometry-based clinical lipidomics
S Salihovic, S Lamichane, T Hyötyläinen… - Current opinion in …, 2023 - Elsevier
The objective of this review is to provide a comprehensive summary of the latest
methodological advancements and emerging patterns in utilizing lipidomics in clinical …
methodological advancements and emerging patterns in utilizing lipidomics in clinical …
[HTML][HTML] Pre-analytical sample handling standardization for reliable measurement of metabolites and lipids in LC-MS-based clinical research
A Sens, S Rischke, L Hahnefeld, E Dorochow… - Journal of Mass …, 2023 - Elsevier
The emerging disciplines of lipidomics and metabolomics show great potential for the
discovery of diagnostic biomarkers, but appropriate pre-analytical sample-handling …
discovery of diagnostic biomarkers, but appropriate pre-analytical sample-handling …
Trip13 depletion in liver cancer induces a lipogenic response contributing to Plin2‐dependent mitotic cell death
M Rios Garcia, B Meissburger, J Chan… - Advanced …, 2022 - Wiley Online Library
Aberrant energy metabolism and cell cycle regulation both critically contribute to malignant
cell growth and both processes represent targets for anticancer therapy. It is shown here that …
cell growth and both processes represent targets for anticancer therapy. It is shown here that …
[HTML][HTML] Development of a targeted hydrophilic interaction liquid chromatography-tandem mass spectrometry based lipidomics platform applied to a coronavirus …
Z Zhang, M Singh, A Kindt, AB Wegrzyn… - … of Chromatography A, 2023 - Elsevier
The importance of lipids seen in studies of metabolism, cancer, the recent COVID-19
pandemic and other diseases has brought the field of lipidomics to the forefront of clinical …
pandemic and other diseases has brought the field of lipidomics to the forefront of clinical …
Omic-scale high-throughput quantitative LC–MS/MS approach for circulatory lipid phenotyping in clinical research
Lipid analysis at the molecular species level represents a valuable opportunity for clinical
applications due to the essential roles that lipids play in metabolic health. However, a …
applications due to the essential roles that lipids play in metabolic health. However, a …