WNT signalling has been studied primarily in developing embryos, in which cells respond to
WNTs in a context-dependent manner through changes in survival and proliferation, cell fate …

Adult Leydig cells (ALCs) are the steroidogenic cells in the testes that produce testosterone.
ALCs develop postnatally from a pool of stem cells, referred to as stem Leydig cells (SLCs) …

The genes encoding members of the wingless-related MMTV integration site (WNT) and
fibroblast growth factor (FGF) families coordinate growth, morphogenesis, and differentiation …

The sex of an individual is determined by the fate of the gonad. While the expression of Sry
and Sox9 is sufficient to induce male development, we here show that female differentiation …

The pivotal point of vertebrate sex determination is the development of the gonad into a
testis or ovary, which governs phenotypic sex through the production of hormones. The …

During mammalian sex determination, expression of the Y-linked gene Sry shifts the
bipotential gonad toward a testicular fate by upregulating a feed-forward loop between FGF9 …

Sex in mammals is genetically determined and is defined at the cellular level by sex
chromosome complement (XY males and XX females). The Y chromosome–linked gene sex …

Nuclear receptors are intracellular proteins that act as transcription factors. Proteins with
classic nuclear receptor domain structure lacking identified signaling ligands are designated …

In mammals, female development has traditionally been considered a default process in the
absence of the testis-determining gene, Sry. Recently, it has been documented that the gene …

Formerly known as' intersex'conditions, disorders of sex development (DSDs) are congenital
conditions in which chromosomal, gonadal or anatomical sex is atypical. A complete …