Metronomic chemotherapy

ME Cazzaniga, N Cordani, S Capici, V Cogliati, F Riva… - Cancers, 2021 - mdpi.com
Simple Summary The present article reviews the state of the art of metronomic
chemotherapy use to treat the principal types of cancers, namely breast, non-small cell lung …

Metronomic capecitabine as adjuvant therapy in locoregionally advanced nasopharyngeal carcinoma: a multicentre, open-label, parallel-group, randomised …

YP Chen, X Liu, Q Zhou, KY Yang, F Jin, XD Zhu, M Shi… - The Lancet, 2021 - thelancet.com
Background Patients with locoregionally advanced nasopharyngeal carcinoma have a high
risk of disease relapse, despite a high proportion of patients attaining complete clinical …

Low-dose immunotherapy in head and neck cancer: a randomized study

VM Patil, V Noronha, N Menon, R Rai… - Journal of Clinical …, 2023 - ingentaconnect.com
PURPOSE The regimens approved for the treatment of advanced head and neck squamous
cell carcinoma are accessible to only 1%-3% of patients in low-and middle-income countries …

BOIN12: Bayesian optimal interval phase I/II trial design for utility-based dose finding in immunotherapy and targeted therapies

R Lin, Y Zhou, F Yan, D Li, Y Yuan - JCO precision oncology, 2020 - ascopubs.org
PURPOSE For immunotherapy, such as checkpoint inhibitors and chimeric antigen receptor
T-cell therapy, where the efficacy does not necessarily increase with the dose, the maximum …

COVID-19 and head and neck cancer treatment

V Patil, V Noronha, P Chaturvedi… - Cancer Research …, 2020 - journals.lww.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic is exponentially increasing,
as are the risks of COVID-related complications and fatalities. Hence, health-care resources …

Low-cost oral metronomic chemotherapy versus intravenous cisplatin in patients with recurrent, metastatic, inoperable head and neck carcinoma: an open-label …

V Patil, V Noronha, SB Dhumal, A Joshi… - The Lancet Global …, 2020 - thelancet.com
Background Regimens for palliation in patients with head and neck cancer recommended
by the US National Comprehensive Cancer Network (NCCN) have low applicability (less …

Nivolumab in platinum-refractory head-and-neck cancers: A retrospective observational audit from a tertiary cancer center

VM Patil, H Muthuluri, J Choudhary… - Cancer Research …, 2022 - journals.lww.com
Background: Nivolumab and pembrolizumab are approved treatment options for platinum-
refractory head-and-neck squamous cell cancer (HNSCC) based on the demonstration of …

The pattern of care in head-and-neck cancer: Comparison between before and during the COVID-19 pandemic

VM Patil, A Srikanth, V Noronha, A Joshi… - Cancer Research …, 2020 - journals.lww.com
Background: Coronavirus disease 2019 (COVID-19) has led to a redistribution of the
medical resources. However, there are limited data on the treatment patterns in head-and …

A mechanistic Review of methotrexate and celecoxib as a potential metronomic chemotherapy for oral squamous cell carcinoma

MV Kamal, M Rao, RR Damerla, A Pai… - Cancer …, 2023 - Taylor & Francis
The combination of low-dose methotrexate and celecoxib as metronomic chemotherapy
(MCT) is a novel therapy, believed to act by modulating the immune response, inhibiting …

Beyond conventional chemotherapy, targeted therapy and immunotherapy in squamous cell cancer of the oral cavity

VM Patil, V Noronha, A Joshi, A Abhyankar, N Menon… - Oral Oncology, 2020 - Elsevier
The focus of this review article is to throw light on non-conventional systemic chemotherapy
that affects the tumour microenvironment and potentially has a favourable impact on the …