Spinocerebellar ataxia type 3 (SCA3), or Machado–Joseph disease (MJD), is an inherited
polyglutamine (polyQ) neurodegenerative disease and the most common form of SCA …

To explore the role of the small heat shock protein beta 1 (HspB1, also known as Hsp25 in
rodents and Hsp27 in humans) in longevity, we created a Caenorhabiditis elegans model …

Biomolecular corona formed on nanoparticles (NPs) influences the latter's in vivo biological
effects. Nanomaterials with different physicochemical properties exert similar adverse …

Functional networks in cells are created by physical, genetic, and regulatory interactions.
Mapping them and annotating their functions by available methods remains a challenge. We …

The number of genes implicated in neurodevelopmental conditions is rapidly growing.
Recently, variants in PPP2R1A have been associated with syndromic intellectual disability …

The aggresome is a protein turnover system in which proteins are trafficked along
microtubules to the centrosome for degradation. Despite extensive focus on aggresomes in …

The naked mole-rat (NMR) is a fascinating animal which has unique biological features
including eusociality, strict subterranean inhabitation and poikilothermy. It is the longest …

Neurogenesis persists but dramatically declines during early aging due to a decreased
capacity of neural stem cells (NSCs) to exit quiescence. Although there is much we know …